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- W2072071750 abstract "Nicotine, a main addictive compound in tobacco smoke, has been linked to promotion and progression of lung, head and neck, pancreatic, and breast cancers, but the detailed mechanisms of cancer progression remain elusive. Here, we show that nicotine induces the expression of galectin-3 (an anti-apoptotic β-galactoside-binding lectin) in breast cancer cell line and in primary tumors from breast cancer patients. Nicotine-induced up regulation of galectin-3 is due to an increased expression of α9 isoform of nicotinic acetylcholine receptor (α9nAChR), which activates transcription factor STAT3 that in turn, physically binds to galectin-3 (LGALS3) promoter and induces transcription of galectin-3. Intracellular galectin-3 increased mitochondrial integrity and suppressed chemotherapeutic-induced apoptosis of breast cancer cell. Moreover, nicotine-induced enrichment of side population cells with cancer stem cell-like properties was modulated by galectin-3 expression and could be significantly reduced by transient knock down of LGALS3 and its upstream signaling molecules STAT3 and α9nAChR. Thus, galectin-3 or its upstream signaling molecule STAT3 or α9nAChR could be a potential target to prevent nicotine-induced chemoresistance in breast cancer." @default.
- W2072071750 created "2016-06-24" @default.
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- W2072071750 date "2014-03-26" @default.
- W2072071750 modified "2023-09-26" @default.
- W2072071750 title "Nicotine promotes apoptosis resistance of breast cancer cells and enrichment of side population cells with cancer stem cell-like properties via a signaling cascade involving galectin-3, α9 nicotinic acetylcholine receptor and STAT3" @default.
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- W2072071750 cites W1877972222 @default.
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- W2072071750 cites W1984201164 @default.
- W2072071750 cites W1992690905 @default.
- W2072071750 cites W2001670844 @default.
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- W2072071750 cites W2007939915 @default.
- W2072071750 cites W2010317454 @default.
- W2072071750 cites W2011253696 @default.
- W2072071750 cites W2012366379 @default.
- W2072071750 cites W2014622924 @default.
- W2072071750 cites W2022549451 @default.
- W2072071750 cites W2024282024 @default.
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- W2072071750 doi "https://doi.org/10.1007/s10549-014-2912-z" @default.
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