FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2072079057> ?p ?o ?g. }

• W2072079057 endingPage "963" @default.
• W2072079057 startingPage "955" @default.
• W2072079057 abstract "Inflammation is one of the main contributors to atherosclerosis in haemodialysis (HD) patients. Activation of Toll-like receptors (TLRs) leads to inflammatory response. In this study, we aimed to evaluate the expression of TLRs on monocytes and relate their expression with inflammation in chronic kidney disease (CKD) and HD patients.Thirty-four age- and gender-matched controls and stage 3-4 CKD patients and thirty-two HD patients were included in each study group. The effect of HD on the expression of Toll-like receptor-2 (TLR-2) and Toll-like receptor-4 (TLR-4) on CD14( +) monocytes was determined at the beginning (baseline), during (120 min) and following (300 min and 24 h) HD and compared with control and stage 3-4 CKD groups. The HD procedure was performed by using low-flux polysulphone dialysers. In addition, serum IL-6 levels were evaluated in both groups at baseline and after a HD session.The percentage of CD14( +) monocytes expressing TLR-2 were similar in all of the study groups, whereas the percentage of CD14( +) monocytes expressing TLR-4 were significantly lower in both stage 3-4 CKD and HD patients at baseline than in controls. The mean fluorescence intensities (MFI) of TLR-2 were significantly lower in controls than in stage 3-4 CKD and HD patients at baseline. The MFI of TLR-4 was similar in all of the groups. The percentage of CD14( +) monocytes expressing TLR-2 did not change during and after HD. The MFI of TLR-2 decreased at 120 min of HD compared with baseline (1837 ± 672 vs 1650 ± 578, P < 0.05), and recovered back to baseline values at 300 min and at 24 h post-HD. MFI of TLR-4 increased at 24 h compared with baseline (941 ± 294 vs 1087 ± 441, P < 0.05). Serum IL-6 levels correlated with MFI of TLR-2 and TLR-4 in stage 3-4 CKD patients and in HD patients at baseline and after HD in univariate analysis. Stepwise multiple regression analysis revealed that MFI of TLR-2 was an independent determinant of serum IL-6 concentrations in stage 3-4 CKD and in HD patients at baseline, at 300 min and at 24 h post-HD. Conclusions. Our study demonstrates that TLR-2 is associated with the inflammatory response of non-dialysed and dialysed CKD patients." @default.
• W2072079057 created "2016-06-24" @default.
• W2072079057 creator A5009311681 @default.
• W2072079057 creator A5012495258 @default.
• W2072079057 creator A5012533725 @default.
• W2072079057 creator A5022538126 @default.
• W2072079057 creator A5031213103 @default.
• W2072079057 creator A5037851552 @default.
• W2072079057 creator A5052789767 @default.
• W2072079057 creator A5071177987 @default.
• W2072079057 creator A5083345780 @default.
• W2072079057 creator A5085120063 @default.
• W2072079057 creator A5085411944 @default.
• W2072079057 date "2010-08-20" @default.
• W2072079057 modified "2023-10-18" @default.
• W2072079057 title "Toll-like receptor expression in monocytes in patients with chronic kidney disease and haemodialysis: relation with inflammation" @default.
• W2072079057 cites W1944492097 @default.
• W2072079057 cites W1959467458 @default.
• W2072079057 cites W1970304016 @default.
• W2072079057 cites W1973677588 @default.
• W2072079057 cites W1988232165 @default.
• W2072079057 cites W1988630397 @default.
• W2072079057 cites W1996691330 @default.
• W2072079057 cites W2004465286 @default.
• W2072079057 cites W2007574728 @default.
• W2072079057 cites W2009732007 @default.
• W2072079057 cites W2014731329 @default.
• W2072079057 cites W2016190795 @default.
• W2072079057 cites W2020272559 @default.
• W2072079057 cites W2024566038 @default.
• W2072079057 cites W2024803597 @default.
• W2072079057 cites W2032882362 @default.
• W2072079057 cites W2038460784 @default.
• W2072079057 cites W2051969301 @default.
• W2072079057 cites W2052648717 @default.
• W2072079057 cites W2058801589 @default.
• W2072079057 cites W2074309896 @default.
• W2072079057 cites W2092380533 @default.
• W2072079057 cites W2101085710 @default.
• W2072079057 cites W2109489066 @default.
• W2072079057 cites W2115626518 @default.
• W2072079057 cites W2123043501 @default.
• W2072079057 cites W2124251682 @default.
• W2072079057 cites W2133449490 @default.
• W2072079057 cites W2156195451 @default.
• W2072079057 cites W2282548675 @default.
• W2072079057 cites W4232411370 @default.
• W2072079057 doi "https://doi.org/10.1093/ndt/gfq500" @default.
• W2072079057 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20729266" @default.
• W2072079057 hasPublicationYear "2010" @default.
• W2072079057 type Work @default.
• W2072079057 sameAs 2072079057 @default.
• W2072079057 citedByCount "50" @default.
• W2072079057 countsByYear W20720790572012 @default.
• W2072079057 countsByYear W20720790572013 @default.
• W2072079057 countsByYear W20720790572014 @default.
• W2072079057 countsByYear W20720790572015 @default.
• W2072079057 countsByYear W20720790572016 @default.
• W2072079057 countsByYear W20720790572017 @default.
• W2072079057 countsByYear W20720790572018 @default.
• W2072079057 countsByYear W20720790572019 @default.
• W2072079057 countsByYear W20720790572020 @default.
• W2072079057 countsByYear W20720790572022 @default.
• W2072079057 countsByYear W20720790572023 @default.
• W2072079057 crossrefType "journal-article" @default.
• W2072079057 hasAuthorship W2072079057A5009311681 @default.
• W2072079057 hasAuthorship W2072079057A5012495258 @default.
• W2072079057 hasAuthorship W2072079057A5012533725 @default.
• W2072079057 hasAuthorship W2072079057A5022538126 @default.
• W2072079057 hasAuthorship W2072079057A5031213103 @default.
• W2072079057 hasAuthorship W2072079057A5037851552 @default.
• W2072079057 hasAuthorship W2072079057A5052789767 @default.
• W2072079057 hasAuthorship W2072079057A5071177987 @default.
• W2072079057 hasAuthorship W2072079057A5083345780 @default.
• W2072079057 hasAuthorship W2072079057A5085120063 @default.
• W2072079057 hasAuthorship W2072079057A5085411944 @default.
• W2072079057 hasBestOaLocation W20720790571 @default.
• W2072079057 hasConcept C126322002 @default.
• W2072079057 hasConcept C134018914 @default.
• W2072079057 hasConcept C136449434 @default.
• W2072079057 hasConcept C170493617 @default.
• W2072079057 hasConcept C203014093 @default.
• W2072079057 hasConcept C2776709828 @default.
• W2072079057 hasConcept C2776914184 @default.
• W2072079057 hasConcept C2778513237 @default.
• W2072079057 hasConcept C2778653478 @default.
• W2072079057 hasConcept C2779978075 @default.
• W2072079057 hasConcept C2781184567 @default.
• W2072079057 hasConcept C71924100 @default.
• W2072079057 hasConcept C90924648 @default.
• W2072079057 hasConceptScore W2072079057C126322002 @default.
• W2072079057 hasConceptScore W2072079057C134018914 @default.
• W2072079057 hasConceptScore W2072079057C136449434 @default.
• W2072079057 hasConceptScore W2072079057C170493617 @default.
• W2072079057 hasConceptScore W2072079057C203014093 @default.
• W2072079057 hasConceptScore W2072079057C2776709828 @default.
• W2072079057 hasConceptScore W2072079057C2776914184 @default.
• W2072079057 hasConceptScore W2072079057C2778513237 @default.

• next