FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2072079193> ?p ?o ?g. }

• W2072079193 endingPage "556" @default.
• W2072079193 startingPage "546" @default.
• W2072079193 abstract "The purposes of the present study were to define precisely the ultrastructural features of apoptosis in cultured cardiomyocytes and to determine whether DNA fragmentation is essential for the apoptotic morphology. When cultured neonatal murine cardiomyocytes were incubated with an agonistic anti-Fas antibody in the presence of a non-toxic amount of actinomycin D or cycloheximide, approximately 70% of them had lost their viability after 24 h. The dead cardiomyocytes showed the typical ultrastructural changes of apoptosis on transmission and scanning electron microscopy, as well as by positive in situ nick end-labelling (TUNEL), positive Taq polymerase-based in situ ligation, a DNA ladder pattern on gel electrophoresis, and an increase in the active fragment of caspase-3. According to TUNEL at the electron microscopic level, apoptotic nuclear change, cytoplasmic shrinkage, and DNA fragmentation always occurred simultaneously in apoptotic cardiomyocytes. Other ultrastructural features of apoptosis were the appearance of abundant lipid-like structures in the cytoplasm of cardiomyocytes at the early phase, and a high incidence of plasma membrane rupture and formation of apoptotic bodies at the later phase. When zinc, an inhibitor of Ca2+/Mg2+-dependent endonuclease, was added to the present model, activation of caspase-3 and an apoptotic ultrastructure were still observed in spite of the lack of DNA fragmentation, indicating that this type of myocyte death is also apoptosis. In conclusion, the typical apoptotic ultrastructure and DNA fragmentation occur simultaneously in association with caspase-3 activation in Fas-stimulated cultured cardiomyocytes. Apoptotic morphology can, however, be observed even without DNA fragmentation." @default.
• W2072079193 created "2016-06-24" @default.
• W2072079193 creator A5004415631 @default.
• W2072079193 creator A5022669876 @default.
• W2072079193 creator A5028040875 @default.
• W2072079193 creator A5040436699 @default.
• W2072079193 creator A5044498041 @default.
• W2072079193 creator A5044584230 @default.
• W2072079193 creator A5064440517 @default.
• W2072079193 creator A5065217658 @default.
• W2072079193 creator A5066511998 @default.
• W2072079193 creator A5077773904 @default.
• W2072079193 creator A5082894446 @default.
• W2072079193 creator A5087541787 @default.
• W2072079193 date "2001-01-01" @default.
• W2072079193 modified "2023-10-16" @default.
• W2072079193 title "Characterization of ultrastructure and its relation with DNA fragmentation in Fas-induced apoptosis of cultured cardiac myocytes" @default.
• W2072079193 cites W1559184092 @default.
• W2072079193 cites W1585483493 @default.
• W2072079193 cites W1591022300 @default.
• W2072079193 cites W1845459216 @default.
• W2072079193 cites W1915857360 @default.
• W2072079193 cites W1967128858 @default.
• W2072079193 cites W1970729738 @default.
• W2072079193 cites W1972185183 @default.
• W2072079193 cites W1986352756 @default.
• W2072079193 cites W2002503549 @default.
• W2072079193 cites W2007604755 @default.
• W2072079193 cites W2012292879 @default.
• W2072079193 cites W2021096466 @default.
• W2072079193 cites W2033529194 @default.
• W2072079193 cites W2047168565 @default.
• W2072079193 cites W2049110705 @default.
• W2072079193 cites W2067534266 @default.
• W2072079193 cites W2075116129 @default.
• W2072079193 cites W2081948388 @default.
• W2072079193 cites W2084609653 @default.
• W2072079193 cites W2086358092 @default.
• W2072079193 cites W2120278715 @default.
• W2072079193 cites W2120751716 @default.
• W2072079193 cites W2137274119 @default.
• W2072079193 cites W2142792362 @default.
• W2072079193 cites W2144693788 @default.
• W2072079193 cites W2145771428 @default.
• W2072079193 cites W2157201513 @default.
• W2072079193 cites W2161968975 @default.
• W2072079193 cites W2164260706 @default.
• W2072079193 doi "https://doi.org/10.1002/1096-9896(2000)9999:9999<::aid-path794>3.0.co;2-l" @default.
• W2072079193 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11276016" @default.
• W2072079193 hasPublicationYear "2001" @default.
• W2072079193 type Work @default.
• W2072079193 sameAs 2072079193 @default.
• W2072079193 citedByCount "53" @default.
• W2072079193 countsByYear W20720791932012 @default.
• W2072079193 countsByYear W20720791932013 @default.
• W2072079193 countsByYear W20720791932014 @default.
• W2072079193 countsByYear W20720791932016 @default.
• W2072079193 countsByYear W20720791932017 @default.
• W2072079193 countsByYear W20720791932018 @default.
• W2072079193 countsByYear W20720791932019 @default.
• W2072079193 countsByYear W20720791932020 @default.
• W2072079193 countsByYear W20720791932021 @default.
• W2072079193 countsByYear W20720791932023 @default.
• W2072079193 crossrefType "journal-article" @default.
• W2072079193 hasAuthorship W2072079193A5004415631 @default.
• W2072079193 hasAuthorship W2072079193A5022669876 @default.
• W2072079193 hasAuthorship W2072079193A5028040875 @default.
• W2072079193 hasAuthorship W2072079193A5040436699 @default.
• W2072079193 hasAuthorship W2072079193A5044498041 @default.
• W2072079193 hasAuthorship W2072079193A5044584230 @default.
• W2072079193 hasAuthorship W2072079193A5064440517 @default.
• W2072079193 hasAuthorship W2072079193A5065217658 @default.
• W2072079193 hasAuthorship W2072079193A5066511998 @default.
• W2072079193 hasAuthorship W2072079193A5077773904 @default.
• W2072079193 hasAuthorship W2072079193A5082894446 @default.
• W2072079193 hasAuthorship W2072079193A5087541787 @default.
• W2072079193 hasConcept C105702510 @default.
• W2072079193 hasConcept C153911025 @default.
• W2072079193 hasConcept C18903297 @default.
• W2072079193 hasConcept C190283241 @default.
• W2072079193 hasConcept C191015642 @default.
• W2072079193 hasConcept C196795494 @default.
• W2072079193 hasConcept C2910232053 @default.
• W2072079193 hasConcept C31573885 @default.
• W2072079193 hasConcept C43759708 @default.
• W2072079193 hasConcept C55493867 @default.
• W2072079193 hasConcept C86803240 @default.
• W2072079193 hasConcept C87439868 @default.
• W2072079193 hasConcept C87555872 @default.
• W2072079193 hasConcept C95444343 @default.
• W2072079193 hasConceptScore W2072079193C105702510 @default.
• W2072079193 hasConceptScore W2072079193C153911025 @default.
• W2072079193 hasConceptScore W2072079193C18903297 @default.
• W2072079193 hasConceptScore W2072079193C190283241 @default.
• W2072079193 hasConceptScore W2072079193C191015642 @default.
• W2072079193 hasConceptScore W2072079193C196795494 @default.
• W2072079193 hasConceptScore W2072079193C2910232053 @default.
• W2072079193 hasConceptScore W2072079193C31573885 @default.

• next