FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2072085791> ?p ?o ?g. }

• W2072085791 endingPage "316" @default.
• W2072085791 startingPage "316" @default.
• W2072085791 abstract "<h3>Importance</h3> Hemorrhage is the leading cause of death in military trauma and second leading cause of death in civilian trauma. Although many well-established animal models of hemorrhage exist in the trauma and anticoagulant literature, few focus on directly quantitating blood loss. <h3>Objective</h3> To establish and validate a reproducible rodent model of uncontrolled hemorrhage to serve as the foundation for developing therapies for noncompressible torso trauma. <h3>Design, Settings, and Subjects</h3> We developed and evaluated 4 different hemorrhage models using male Sprague-Dawley rats (6 rats/model), aged 10 to 14 weeks and weighing 330 to 460 g, at the Department of Surgery, Northwestern University. <h3>Interventions</h3> We used tail-cut (4 cm), liver punch biopsy (12 mm), liver laceration (3.0 × 1.5 cm), and spleen transection models. All animals underwent invasive hemodynamic monitoring. <h3>Main Outcomes and Measures</h3> Blood loss, expressed as a percentage of total blood volume (TBV), mean arterial pressure, and heart rate, which were recorded at 2- to 5-minute intervals. <h3>Results</h3> The tail-cut model resulted in a mean (SD) TBV loss of 15.4% (6.0%) with hemodynamics consistent with class I hemorrhagic shock. The liver punch biopsy model resulted in a mean (SD) TBV loss of 16.7% (3.3%) with hemodynamics consistent with class I hemorrhagic shock. The liver laceration model resulted in a mean (SD) TBV loss of 19.8% (3.0%) with hemodynamics consistent with class II hemorrhagic shock. The spleen transection model resulted in the greatest blood loss (<i>P</i> < .01), with a mean (SD) TBV loss of 27.9% (3.4%) and hemodynamics consistent with class II hemorrhagic shock. The liver laceration and punch biopsy models resulted in most of the blood loss within the first 2 minutes, whereas the spleen transection and tail-cut models resulted in a steady loss during 10 minutes. The liver laceration and spleen transection models resulted in the greatest degree of hemodynamic instability (mean [SD] arterial pressure decreases of 25 [1] and 41 [11] mm Hg, respectively). One-hour survival was 100% in all 4 models. <h3>Conclusions and Relevance</h3> We established and validated the reproducibility of 4 different rat models of uncontrolled hemorrhage. These models provide a foundation to design novel nonsurgical therapies to control hemorrhage, and the different degrees of hemorrhagic shock produced from these models allow for flexibility in experimental design." @default.
• W2072085791 created "2016-06-24" @default.
• W2072085791 creator A5021095261 @default.
• W2072085791 creator A5046307546 @default.
• W2072085791 creator A5060077166 @default.
• W2072085791 creator A5083332793 @default.
• W2072085791 creator A5091531983 @default.
• W2072085791 date "2015-04-01" @default.
• W2072085791 modified "2023-10-16" @default.
• W2072085791 title "Development and Validation of 4 Different Rat Models of Uncontrolled Hemorrhage" @default.
• W2072085791 cites W1575823155 @default.
• W2072085791 cites W1785859164 @default.
• W2072085791 cites W1853052369 @default.
• W2072085791 cites W1995679644 @default.
• W2072085791 cites W1996587671 @default.
• W2072085791 cites W1998440459 @default.
• W2072085791 cites W2007551054 @default.
• W2072085791 cites W2010094703 @default.
• W2072085791 cites W2010202412 @default.
• W2072085791 cites W2018113282 @default.
• W2072085791 cites W2021421795 @default.
• W2072085791 cites W2037719820 @default.
• W2072085791 cites W2052878904 @default.
• W2072085791 cites W2067444728 @default.
• W2072085791 cites W2088117829 @default.
• W2072085791 cites W2090540596 @default.
• W2072085791 cites W2092984420 @default.
• W2072085791 cites W2100184168 @default.
• W2072085791 cites W2117661477 @default.
• W2072085791 doi "https://doi.org/10.1001/jamasurg.2014.1685" @default.
• W2072085791 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25693160" @default.
• W2072085791 hasPublicationYear "2015" @default.
• W2072085791 type Work @default.
• W2072085791 sameAs 2072085791 @default.
• W2072085791 citedByCount "25" @default.
• W2072085791 countsByYear W20720857912015 @default.
• W2072085791 countsByYear W20720857912016 @default.
• W2072085791 countsByYear W20720857912017 @default.
• W2072085791 countsByYear W20720857912018 @default.
• W2072085791 countsByYear W20720857912019 @default.
• W2072085791 countsByYear W20720857912020 @default.
• W2072085791 countsByYear W20720857912021 @default.
• W2072085791 countsByYear W20720857912022 @default.
• W2072085791 countsByYear W20720857912023 @default.
• W2072085791 crossrefType "journal-article" @default.
• W2072085791 hasAuthorship W2072085791A5021095261 @default.
• W2072085791 hasAuthorship W2072085791A5046307546 @default.
• W2072085791 hasAuthorship W2072085791A5060077166 @default.
• W2072085791 hasAuthorship W2072085791A5083332793 @default.
• W2072085791 hasAuthorship W2072085791A5091531983 @default.
• W2072085791 hasConcept C126322002 @default.
• W2072085791 hasConcept C141071460 @default.
• W2072085791 hasConcept C164705383 @default.
• W2072085791 hasConcept C178853913 @default.
• W2072085791 hasConcept C2776452961 @default.
• W2072085791 hasConcept C2777953023 @default.
• W2072085791 hasConcept C2780931953 @default.
• W2072085791 hasConcept C2781300812 @default.
• W2072085791 hasConcept C2781309813 @default.
• W2072085791 hasConcept C37557685 @default.
• W2072085791 hasConcept C42219234 @default.
• W2072085791 hasConcept C71924100 @default.
• W2072085791 hasConcept C84393581 @default.
• W2072085791 hasConceptScore W2072085791C126322002 @default.
• W2072085791 hasConceptScore W2072085791C141071460 @default.
• W2072085791 hasConceptScore W2072085791C164705383 @default.
• W2072085791 hasConceptScore W2072085791C178853913 @default.
• W2072085791 hasConceptScore W2072085791C2776452961 @default.
• W2072085791 hasConceptScore W2072085791C2777953023 @default.
• W2072085791 hasConceptScore W2072085791C2780931953 @default.
• W2072085791 hasConceptScore W2072085791C2781300812 @default.
• W2072085791 hasConceptScore W2072085791C2781309813 @default.
• W2072085791 hasConceptScore W2072085791C37557685 @default.
• W2072085791 hasConceptScore W2072085791C42219234 @default.
• W2072085791 hasConceptScore W2072085791C71924100 @default.
• W2072085791 hasConceptScore W2072085791C84393581 @default.
• W2072085791 hasIssue "4" @default.
• W2072085791 hasLocation W20720857911 @default.
• W2072085791 hasLocation W20720857912 @default.
• W2072085791 hasOpenAccess W2072085791 @default.
• W2072085791 hasPrimaryLocation W20720857911 @default.
• W2072085791 hasRelatedWork W1509441552 @default.
• W2072085791 hasRelatedWork W1541936478 @default.
• W2072085791 hasRelatedWork W2014768598 @default.
• W2072085791 hasRelatedWork W2015183528 @default.
• W2072085791 hasRelatedWork W2018097748 @default.
• W2072085791 hasRelatedWork W2023364661 @default.
• W2072085791 hasRelatedWork W2091604258 @default.
• W2072085791 hasRelatedWork W2116255741 @default.
• W2072085791 hasRelatedWork W2610814222 @default.
• W2072085791 hasRelatedWork W3008180775 @default.
• W2072085791 hasVolume "150" @default.
• W2072085791 isParatext "false" @default.
• W2072085791 isRetracted "false" @default.
• W2072085791 magId "2072085791" @default.
• W2072085791 workType "article" @default.