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- W2072088482 abstract "Alternative pre-mRNA splicing is a major cellular process by which functionally diverse proteins can be generated from the primary transcript of a single gene, often in tissue-specific patterns. The current study investigates the hypothesis that splicing of tissue-specific alternative exons is regulated in part by control sequences in adjacent introns and that such elements may be recognized via computational analysis of exons sharing a highly specific expression pattern. We have identified 25 brain-specific alternative cassette exons, compiled a dataset of genomic sequences encompassing these exons and their adjacent introns and used word contrast algorithms to analyze key features of these nucleotide sequences. By comparison to a control group of constitutive exons, brain-specific exons were often found to possess the following: divergent 5' splice sites; highly pyrimidine-rich upstream introns; a paucity of GGG motifs in the downstream intron; a highly statistically significant over-representation of the hexanucleotide UGCAUG in the proximal downstream intron. UGCAUG was also found at a high frequency downstream of a smaller group of muscle-specific exons. Intriguingly, UGCAUG has been identified previously in a few intron splicing enhancers. Our results indicate that this element plays a much wider role than previously appreciated in the regulated tissue-specific splicing of many alternative exons." @default.
- W2072088482 created "2016-06-24" @default.
- W2072088482 creator A5012113499 @default.
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- W2072088482 date "2001-06-01" @default.
- W2072088482 modified "2023-10-13" @default.
- W2072088482 title "Computational analysis of candidate intron regulatory elements for tissue-specific alternative pre-mRNA splicing" @default.
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- W2072088482 doi "https://doi.org/10.1093/nar/29.11.2338" @default.
- W2072088482 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/55704" @default.
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