Matches in SemOpenAlex for { <https://semopenalex.org/work/W2072088834> ?p ?o ?g. }
- W2072088834 endingPage "493" @default.
- W2072088834 startingPage "461" @default.
- W2072088834 abstract "In smooth muscle, Ca2+ controls diverse activities including cell division, contraction and cell death. Of particular significance in enabling Ca2+ to perform these multiple functions is the cell's ability to localize Ca2+ signals to certain regions by creating high local concentrations of Ca2+ (microdomains), which differ from the cytoplasmic average. Microdomains arise from Ca2+ influx across the plasma membrane or release from the sarcoplasmic reticulum (SR) Ca2+ store. A single Ca2+ channel can create a microdomain of several micromolar near (∼200 nm) the channel. This concentration declines quickly with peak rates of several thousand micromolar per second when influx ends. The high [Ca2+] and the rapid rates of decline target Ca2+ signals to effectors in the microdomain with rapid kinetics and enable the selective activation of cellular processes. Several elements within the cell combine to enable microdomains to develop. These include the brief open time of ion channels, localization of Ca2+ by buffering, the clustering of ion channels to certain regions of the cell and the presence of membrane barriers, which restrict the free diffusion of Ca2+. In this review, the generation of microdomains arising from Ca2+ influx across the plasma membrane and the release of the ion from the SR Ca2+ store will be discussed and the contribution of mitochondria and the Golgi apparatus as well as endogenous modulators (e.g. cADPR and channel binding proteins) will be considered." @default.
- W2072088834 created "2016-06-24" @default.
- W2072088834 creator A5005927425 @default.
- W2072088834 creator A5030229064 @default.
- W2072088834 creator A5035766723 @default.
- W2072088834 creator A5041961469 @default.
- W2072088834 creator A5072011531 @default.
- W2072088834 date "2006-11-01" @default.
- W2072088834 modified "2023-10-16" @default.
- W2072088834 title "Ca2+ microdomains in smooth muscle" @default.
- W2072088834 cites W130501137 @default.
- W2072088834 cites W144120563 @default.
- W2072088834 cites W1514546358 @default.
- W2072088834 cites W1518598287 @default.
- W2072088834 cites W1520756199 @default.
- W2072088834 cites W1525636180 @default.
- W2072088834 cites W1528977425 @default.
- W2072088834 cites W1560835855 @default.
- W2072088834 cites W1565127991 @default.
- W2072088834 cites W1566063705 @default.
- W2072088834 cites W1591439195 @default.
- W2072088834 cites W1599277155 @default.
- W2072088834 cites W1604671970 @default.
- W2072088834 cites W1634159439 @default.
- W2072088834 cites W1635697816 @default.
- W2072088834 cites W1642181682 @default.
- W2072088834 cites W1670760110 @default.
- W2072088834 cites W1676765468 @default.
- W2072088834 cites W1756176550 @default.
- W2072088834 cites W1777057528 @default.
- W2072088834 cites W18180971 @default.
- W2072088834 cites W1851479110 @default.
- W2072088834 cites W1857532475 @default.
- W2072088834 cites W1884656506 @default.
- W2072088834 cites W1888295889 @default.
- W2072088834 cites W1889655230 @default.
- W2072088834 cites W1894088205 @default.
- W2072088834 cites W1900961504 @default.
- W2072088834 cites W1939830031 @default.
- W2072088834 cites W1957111431 @default.
- W2072088834 cites W1963403501 @default.
- W2072088834 cites W1963637372 @default.
- W2072088834 cites W1963880619 @default.
- W2072088834 cites W1964634922 @default.
- W2072088834 cites W1964922201 @default.
- W2072088834 cites W1965021019 @default.
- W2072088834 cites W1965052647 @default.
- W2072088834 cites W1965095855 @default.
- W2072088834 cites W1965270044 @default.
- W2072088834 cites W1966307177 @default.
- W2072088834 cites W1967463041 @default.
- W2072088834 cites W1968026904 @default.
- W2072088834 cites W1968530770 @default.
- W2072088834 cites W1968789295 @default.
- W2072088834 cites W1968926794 @default.
- W2072088834 cites W1969894123 @default.
- W2072088834 cites W1970379941 @default.
- W2072088834 cites W1971096671 @default.
- W2072088834 cites W1971639385 @default.
- W2072088834 cites W1971754413 @default.
- W2072088834 cites W1974040612 @default.
- W2072088834 cites W1974535915 @default.
- W2072088834 cites W1976151623 @default.
- W2072088834 cites W1976245812 @default.
- W2072088834 cites W1976348423 @default.
- W2072088834 cites W1976527906 @default.
- W2072088834 cites W1976741834 @default.
- W2072088834 cites W1977201959 @default.
- W2072088834 cites W1977369347 @default.
- W2072088834 cites W1977712969 @default.
- W2072088834 cites W1977736675 @default.
- W2072088834 cites W1978691820 @default.
- W2072088834 cites W1978879981 @default.
- W2072088834 cites W1979002457 @default.
- W2072088834 cites W1979306509 @default.
- W2072088834 cites W1980118752 @default.
- W2072088834 cites W1980245772 @default.
- W2072088834 cites W1980824303 @default.
- W2072088834 cites W1981016365 @default.
- W2072088834 cites W1981075941 @default.
- W2072088834 cites W1984321928 @default.
- W2072088834 cites W1984324503 @default.
- W2072088834 cites W1984754431 @default.
- W2072088834 cites W1984873108 @default.
- W2072088834 cites W1984877393 @default.
- W2072088834 cites W1986124091 @default.
- W2072088834 cites W1986164310 @default.
- W2072088834 cites W1986684354 @default.
- W2072088834 cites W1987651912 @default.
- W2072088834 cites W1987984932 @default.
- W2072088834 cites W1988146103 @default.
- W2072088834 cites W1990220309 @default.
- W2072088834 cites W1991002565 @default.
- W2072088834 cites W1991753089 @default.
- W2072088834 cites W1991811424 @default.
- W2072088834 cites W1992200710 @default.
- W2072088834 cites W1992527377 @default.
- W2072088834 cites W1992832047 @default.