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- W2072090007 abstract "Tumor progression can be understood as a collaborative effort of mutations and growth factors, which propels cell proliferation and matrix invasion, and also enables evasion of drug‐induced apoptosis. Concentrating on EGFR, we discuss downstream signaling and the initiation of transcriptional events in response to growth factors. Specifically, we portray a wave‐like program, which initiates by rapid disappearance of two‐dozen microRNAs, followed by an abrupt rise of immediate early genes (IEGs), relatively short transcripts encoding transcriptional regulators. Concurrent with the fall of IEGs, some 30–60 min after stimulation, a larger group, the delayed early genes, is up‐regulated and its own fall overlaps the rise of the final wave of late response genes. This late wave persists and determines long‐term phenotype acquisition, such as invasiveness. Key regulatory steps in the orderly response to growth factors provide a trove of potential oncogenes and tumor suppressors." @default.
- W2072090007 created "2016-06-24" @default.
- W2072090007 creator A5038055187 @default.
- W2072090007 creator A5067213450 @default.
- W2072090007 date "2014-05-27" @default.
- W2072090007 modified "2023-09-26" @default.
- W2072090007 title "Steering tumor progression through the transcriptional response to growth factors and stroma" @default.
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- W2072090007 doi "https://doi.org/10.1016/j.febslet.2014.05.036" @default.
- W2072090007 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4096583" @default.
- W2072090007 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24873881" @default.
- W2072090007 hasPublicationYear "2014" @default.
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