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• W2072092279 abstract "It has been hypothesized that Alzheimer's disease (AD) is caused by an accumulation of damage in DNA due to defective DNA-repair (21). Attempts to test this hypothesis by determining the activity of DNA-repair systems in nonneuronal cells from AD patients and controls so far provided conflicting results. An alternative approach is the direct comparison of DNA-damage levels in neuronal tissue of AD patients and controls. In the present study we assayed the level of DNA breaks and alkali-labile sites in cerebral cortex tissue samples from AD patients and controls obtained from rapid autopsies. Our data on 11 AD patients and 8 control subjects indicate an at least two-fold higher level of DNA damage in cortex of AD patients as compared to controls." @default.
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• W2072092279 date "1990-05-01" @default.
• W2072092279 modified "2023-10-06" @default.
• W2072092279 title "Increased levels of DNA breaks in cerebral cortex of Alzheimer's disease patients" @default.
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• W2072092279 doi "https://doi.org/10.1016/0197-4580(90)90542-8" @default.
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