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- W2072100094 abstract "L’utilisation de l’amikacine est délicate en raison de sa toxicité et de sa variabilité pharmacocinétique. Cette variabilité est pratiquement ignorée chez l’adulte puisque seul le poids est utilisé dans le calcul de la dose à administrer. Notre objectif est de tester si la pharmacocinétique de l’amikacine peut être considérée comme homogène, et si le mode de calcul de la dose en fonction du poids est adapté. À partir d’une cohorte de 580 patients, cinq groupes homogènes de patients ont été créés par partitionnement de données. Une analyse de pharmacocinétique de population a été effectuée dans chaque groupe. La population adulte n’est pas homogène au niveau pharmacocinétique. Les doses nécessaires pour atteindre une concentration maximale de 60 mg/L sont fortement différentes (585 à 1507 mg). L’utilisation exclusive du poids pour calculer la dose à administrer est inappropriée dans 80 % des cas, montrant les limites des formules de calcul des doses d’aminosides. The use of amikacin is difficult because of its toxicity and its pharmacokinetic variability. This variability is almost ignored in adult standard dosage regimens since only the weight is used in the dose calculation. Our objective is to test if the pharmacokinetic of amikacin can be regarded as homogenous, and if the method for calculating the dose according to patients’ weight is appropriate. From a cohort of 580 patients, five groups of patients were created by statistical data partitioning. A population pharmacokinetic analysis was performed in each group. The adult population is not homogeneous in term of pharmacokinetics. The doses required to achieve a maximum concentration of 60 mg/L are strongly different (585 to 1507 mg) between groups. The exclusive use of the weight to calculate the dose of amikacine appears inappropriate for 80% of the patients, showing the limits of the formulae for calculating doses of aminoglycosides." @default.
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- W2072100094 date "2009-01-01" @default.
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- W2072100094 title "Pharmacocinétique de l’amikacine chez l’adulte : une hétérogénéité qui remet en cause le calcul de la dose basé sur le poids" @default.
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- W2072100094 doi "https://doi.org/10.2515/therapie/2009009" @default.
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