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• W2072101828 abstract "A survey is given of the use of chelating agents in the treatment of metal poisonings. 1 The complexing agents in established clinical use are the polyaminopolycarboxylic acid EDTA (ethylenediamine tetraacetate) and the thiols BAL (2, 3-dimercaptopropanol) and D-penicillamine. Desferrioxamine is useful in the treatment of iron overloading. 2 The theoretical foundation of the metal-ligand interaction and some general principles of value in the search for new metal antidotes are outlined. 3 Recent research has shown that 2, 3-dimercaptosuccinic acid (DMS) and 2, 3-dimercaptopropane-1-sulphonate (DMPS) are effective in mercury and arsenic poisonings. 4 DMS and DMPS are of significantly lower toxicity than BAL, and they can be administered orally or intravenously. 5 A particularly low toxicity of DMS is reported from clinical and experimental studies, and this agent may be useful against several metal poisonings including mercury, lead and gold." @default.
• W2072101828 created "2016-06-24" @default.
• W2072101828 creator A5080871218 @default.
• W2072101828 date "1983-04-01" @default.
• W2072101828 modified "2023-09-25" @default.
• W2072101828 title "Recent Advance in the Therapy of Metal Poisonings with Chelating Agents" @default.
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• W2072101828 doi "https://doi.org/10.1177/096032718300200214" @default.
• W2072101828 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6345341" @default.
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