Matches in SemOpenAlex for { <https://semopenalex.org/work/W2072140886> ?p ?o ?g. }
- W2072140886 endingPage "74" @default.
- W2072140886 startingPage "66" @default.
- W2072140886 abstract "Aging alters the skeletal muscle response to overload-induced growth. The onset of functional overload is characterized by increased myoblast proliferation and an altered muscle metabolic profile. The onset of functional overload is associated with increased energy demands that are met through the interconversion of lactate and pyruvate via the activity of lactate dehydrogenase (LDH). Testosterone targets many of the processes activated at the onset of functional overload. However, the effect of aging on this metabolic plasticity at the onset of functional overload and how anabolic steroid administration modulates this response is not well understood. The purpose of this study was to determine if aging would alter overload-induced LDH activity and expression at the onset of functional overload and whether anabolic steroid administration would modulate this response. Five-month and 25-month male Fischer 344 x F1 BRN were given nandrolone decanoate (ND) or sham injections for 14 days and then the plantaris was functionally overloaded (OV) for 3 days by synergist ablation. Aging reduced muscle LDH-A & LDH-B activity 70% (p < 0.05). Aging also reduced LDH-A mRNA abundance, however there was no age effect on LDH-B mRNA abundance. In 5-month muscle, both ND and OV decreased LDH-A and LDH-B activity. However, there was no synergistic or additive effect. In 5-month muscle, ND and OV decreased LDH-A mRNA expression with no change in LDH-B expression. In 25-month muscle, ND and OV increased LDH-A and LDH-B activity. LDH-A mRNA expression was not altered by ND or OV in aged muscle. However, there was a main effect of OV to decrease LDH-B mRNA expression. There was also an age-induced LDH isoform shift. ND and OV treatment increased the “fast” LDH isoforms in aged muscle, whereas ND and OV increased the “slow” isoforms in young muscle. Our study provides evidence that aging alters aspects of skeletal muscle metabolic plasticity normally induced by overload and anabolic steroid administration." @default.
- W2072140886 created "2016-06-24" @default.
- W2072140886 creator A5003306253 @default.
- W2072140886 creator A5006785946 @default.
- W2072140886 creator A5021154775 @default.
- W2072140886 creator A5025320225 @default.
- W2072140886 creator A5084767851 @default.
- W2072140886 date "2014-09-01" @default.
- W2072140886 modified "2023-10-17" @default.
- W2072140886 title "Lactate dehydrogenase regulation in aged skeletal muscle: Regulation by anabolic steroids and functional overload" @default.
- W2072140886 cites W1607366761 @default.
- W2072140886 cites W1769403569 @default.
- W2072140886 cites W1774282859 @default.
- W2072140886 cites W1896085769 @default.
- W2072140886 cites W1897608564 @default.
- W2072140886 cites W1964941751 @default.
- W2072140886 cites W1968362004 @default.
- W2072140886 cites W1974799396 @default.
- W2072140886 cites W1976195583 @default.
- W2072140886 cites W1987122034 @default.
- W2072140886 cites W1989052865 @default.
- W2072140886 cites W1990080814 @default.
- W2072140886 cites W1990435249 @default.
- W2072140886 cites W1993015927 @default.
- W2072140886 cites W1995976459 @default.
- W2072140886 cites W2003330837 @default.
- W2072140886 cites W2009369707 @default.
- W2072140886 cites W2018256248 @default.
- W2072140886 cites W2021089058 @default.
- W2072140886 cites W2023537237 @default.
- W2072140886 cites W2023864698 @default.
- W2072140886 cites W2024920540 @default.
- W2072140886 cites W2030597485 @default.
- W2072140886 cites W2031429117 @default.
- W2072140886 cites W2031482129 @default.
- W2072140886 cites W2034883081 @default.
- W2072140886 cites W2040356368 @default.
- W2072140886 cites W2040950016 @default.
- W2072140886 cites W2041562324 @default.
- W2072140886 cites W2042470379 @default.
- W2072140886 cites W2046196792 @default.
- W2072140886 cites W2054950088 @default.
- W2072140886 cites W2057832619 @default.
- W2072140886 cites W2058218780 @default.
- W2072140886 cites W2061335198 @default.
- W2072140886 cites W2063018637 @default.
- W2072140886 cites W2065541497 @default.
- W2072140886 cites W2083738073 @default.
- W2072140886 cites W2087602854 @default.
- W2072140886 cites W2097286914 @default.
- W2072140886 cites W2100020660 @default.
- W2072140886 cites W2105071743 @default.
- W2072140886 cites W2105508989 @default.
- W2072140886 cites W2109534726 @default.
- W2072140886 cites W2111374783 @default.
- W2072140886 cites W2112991269 @default.
- W2072140886 cites W2124496828 @default.
- W2072140886 cites W2127835340 @default.
- W2072140886 cites W2136743230 @default.
- W2072140886 cites W2137834893 @default.
- W2072140886 cites W2141133711 @default.
- W2072140886 cites W2142483199 @default.
- W2072140886 cites W2143587612 @default.
- W2072140886 cites W2144365152 @default.
- W2072140886 cites W2153505397 @default.
- W2072140886 cites W2153594132 @default.
- W2072140886 cites W2157839661 @default.
- W2072140886 cites W2161955670 @default.
- W2072140886 cites W2164441820 @default.
- W2072140886 cites W2167052162 @default.
- W2072140886 cites W2168961260 @default.
- W2072140886 cites W2169958677 @default.
- W2072140886 cites W2171630877 @default.
- W2072140886 cites W2179021658 @default.
- W2072140886 cites W2256342783 @default.
- W2072140886 cites W2297950240 @default.
- W2072140886 cites W2314719469 @default.
- W2072140886 cites W2323748919 @default.
- W2072140886 cites W2326289669 @default.
- W2072140886 cites W831891907 @default.
- W2072140886 doi "https://doi.org/10.1016/j.exger.2014.05.003" @default.
- W2072140886 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24835193" @default.
- W2072140886 hasPublicationYear "2014" @default.
- W2072140886 type Work @default.
- W2072140886 sameAs 2072140886 @default.
- W2072140886 citedByCount "15" @default.
- W2072140886 countsByYear W20721408862015 @default.
- W2072140886 countsByYear W20721408862016 @default.
- W2072140886 countsByYear W20721408862017 @default.
- W2072140886 countsByYear W20721408862018 @default.
- W2072140886 countsByYear W20721408862020 @default.
- W2072140886 countsByYear W20721408862021 @default.
- W2072140886 countsByYear W20721408862022 @default.
- W2072140886 crossrefType "journal-article" @default.
- W2072140886 hasAuthorship W2072140886A5003306253 @default.
- W2072140886 hasAuthorship W2072140886A5006785946 @default.
- W2072140886 hasAuthorship W2072140886A5021154775 @default.
- W2072140886 hasAuthorship W2072140886A5025320225 @default.