FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2072154601> ?p ?o ?g. }

• W2072154601 endingPage "370" @default.
• W2072154601 startingPage "364" @default.
• W2072154601 abstract "We recently showed that histone H2A.Z, as well as members of the ATP-dependent p400 chromatin remodeling complex (p400.com), are essential components of estrogen receptor alpha (ERalpha) signaling. More specifically, we showed that H2A.Z and p400.com are incorporated into the promoter regions of ERalpha target genes only upon gene induction, and also in a cyclic fashion. RNAi-mediated cellular depletion of H2A.Z and p400.com strongly impedes estrogen-dependent growth of breast cancer cells as well as strongly affect ERalpha-target gene expression. Two mechanisms emerged from our studies of how H2A.Z incorporation within ERalpha-target regulatory regions can actually regulate estrogen-mediated signaling: (1) by stabilizing nucleosomes within the translational DNA axis, a process that allows general transcription factors to be efficiently recruited to promoter regions; (2) by allowing estrogen-responsive enhancer function. In the current study, we now show that in MCF7 cells, ectopic overexpression of H2A.Z increases proliferation, and such in conditions where estrogen levels are low. Also, immunohistochemical studies of breast cancer biopsies show that the presence of H2A.Z correlates highly with that of ERalpha, but is associated with high-grade ER-negative cancers. Finally we show that ERalpha directly associates to the H2A.Z promoter, and consequently modulates its expression. Our study provides a possible link between H2A.Z and endocrine resistance by showing that H2A.Z overexpression leads to increased growth, particularly when estrogen levels are very low." @default.
• W2072154601 created "2016-06-24" @default.
• W2072154601 creator A5009960664 @default.
• W2072154601 creator A5027772328 @default.
• W2072154601 creator A5045617127 @default.
• W2072154601 creator A5060629349 @default.
• W2072154601 date "2010-01-15" @default.
• W2072154601 modified "2023-10-17" @default.
• W2072154601 title "H2A.Z overexpression promotes cellular proliferation of breast cancer cells" @default.
• W2072154601 cites W1565319746 @default.
• W2072154601 cites W1975289899 @default.
• W2072154601 cites W1976525918 @default.
• W2072154601 cites W1982519328 @default.
• W2072154601 cites W1989790390 @default.
• W2072154601 cites W2006818766 @default.
• W2072154601 cites W2013429896 @default.
• W2072154601 cites W2013816574 @default.
• W2072154601 cites W2014039677 @default.
• W2072154601 cites W2032969093 @default.
• W2072154601 cites W2033340114 @default.
• W2072154601 cites W2033856541 @default.
• W2072154601 cites W2040735698 @default.
• W2072154601 cites W2059770482 @default.
• W2072154601 cites W2086385672 @default.
• W2072154601 cites W2088641994 @default.
• W2072154601 cites W2109315379 @default.
• W2072154601 cites W2120948678 @default.
• W2072154601 cites W2122706742 @default.
• W2072154601 cites W2122757134 @default.
• W2072154601 cites W2124201592 @default.
• W2072154601 cites W2133452708 @default.
• W2072154601 cites W2142497951 @default.
• W2072154601 cites W2144654038 @default.
• W2072154601 cites W2146728902 @default.
• W2072154601 cites W2151108285 @default.
• W2072154601 cites W2158657731 @default.
• W2072154601 cites W2160450758 @default.
• W2072154601 cites W2161183329 @default.
• W2072154601 cites W2170728568 @default.
• W2072154601 cites W2172024583 @default.
• W2072154601 cites W2216423518 @default.
• W2072154601 doi "https://doi.org/10.4161/cc.9.2.10465" @default.
• W2072154601 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20023423" @default.
• W2072154601 hasPublicationYear "2010" @default.
• W2072154601 type Work @default.
• W2072154601 sameAs 2072154601 @default.
• W2072154601 citedByCount "79" @default.
• W2072154601 countsByYear W20721546012012 @default.
• W2072154601 countsByYear W20721546012013 @default.
• W2072154601 countsByYear W20721546012014 @default.
• W2072154601 countsByYear W20721546012015 @default.
• W2072154601 countsByYear W20721546012016 @default.
• W2072154601 countsByYear W20721546012017 @default.
• W2072154601 countsByYear W20721546012018 @default.
• W2072154601 countsByYear W20721546012019 @default.
• W2072154601 countsByYear W20721546012020 @default.
• W2072154601 countsByYear W20721546012021 @default.
• W2072154601 countsByYear W20721546012022 @default.
• W2072154601 crossrefType "journal-article" @default.
• W2072154601 hasAuthorship W2072154601A5009960664 @default.
• W2072154601 hasAuthorship W2072154601A5027772328 @default.
• W2072154601 hasAuthorship W2072154601A5045617127 @default.
• W2072154601 hasAuthorship W2072154601A5060629349 @default.
• W2072154601 hasBestOaLocation W20721546011 @default.
• W2072154601 hasConcept C104317684 @default.
• W2072154601 hasConcept C111936080 @default.
• W2072154601 hasConcept C121608353 @default.
• W2072154601 hasConcept C165864922 @default.
• W2072154601 hasConcept C167227067 @default.
• W2072154601 hasConcept C172313692 @default.
• W2072154601 hasConcept C2777164284 @default.
• W2072154601 hasConcept C502942594 @default.
• W2072154601 hasConcept C530470458 @default.
• W2072154601 hasConcept C54355233 @default.
• W2072154601 hasConcept C62112901 @default.
• W2072154601 hasConcept C64927066 @default.
• W2072154601 hasConcept C83640560 @default.
• W2072154601 hasConcept C84606932 @default.
• W2072154601 hasConcept C86339819 @default.
• W2072154601 hasConcept C86803240 @default.
• W2072154601 hasConcept C95444343 @default.
• W2072154601 hasConcept C97037327 @default.
• W2072154601 hasConceptScore W2072154601C104317684 @default.
• W2072154601 hasConceptScore W2072154601C111936080 @default.
• W2072154601 hasConceptScore W2072154601C121608353 @default.
• W2072154601 hasConceptScore W2072154601C165864922 @default.
• W2072154601 hasConceptScore W2072154601C167227067 @default.
• W2072154601 hasConceptScore W2072154601C172313692 @default.
• W2072154601 hasConceptScore W2072154601C2777164284 @default.
• W2072154601 hasConceptScore W2072154601C502942594 @default.
• W2072154601 hasConceptScore W2072154601C530470458 @default.
• W2072154601 hasConceptScore W2072154601C54355233 @default.
• W2072154601 hasConceptScore W2072154601C62112901 @default.
• W2072154601 hasConceptScore W2072154601C64927066 @default.
• W2072154601 hasConceptScore W2072154601C83640560 @default.
• W2072154601 hasConceptScore W2072154601C84606932 @default.
• W2072154601 hasConceptScore W2072154601C86339819 @default.
• W2072154601 hasConceptScore W2072154601C86803240 @default.

• next