Matches in SemOpenAlex for { <https://semopenalex.org/work/W2072156671> ?p ?o ?g. }
- W2072156671 abstract "Caspases are a family of cysteine proteases that are essential in the initiation and execution of apoptosis and the proteolytic maturation of inflammatory cytokines such as IL-1beta and IL-18. Caspases can be subdivided into those that have a large prodomain and those that have not. In general, apoptotic and inflammatory signalling pathways are initiated when large-prodomain caspases are recruited to large protein complexes via homotypic interactions involving death domain folds. The formation of these specialised multimeric platforms involves three major functions: (1) the sensing of cellular stress, damage, infection or inflammation; (2) multimerisation of the platform; and (3) recruitment and conformational activation of caspases. In this overview we discuss the complexes implicated in the regulation of cell death and inflammatory processes such as the death-inducing signalling complex (DISC), the apoptosome, the inflammasomes and the PIDDosome. We describe their sensing functions, compositions and functional outcomes. Inhibitory protein families such as FLIPs and CARD-only proteins prevent the recruitment of caspases in these sensing complexes, avoiding inappropriate initiation of cell death or inflammation." @default.
- W2072156671 created "2016-06-24" @default.
- W2072156671 creator A5014558436 @default.
- W2072156671 creator A5083859184 @default.
- W2072156671 creator A5089113838 @default.
- W2072156671 creator A5089980453 @default.
- W2072156671 date "2006-01-01" @default.
- W2072156671 modified "2023-09-25" @default.
- W2072156671 title "Caspase-containing complexes in the regulation of cell death and inflammation" @default.
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