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- W2072156712 endingPage "145" @default.
- W2072156712 startingPage "116" @default.
- W2072156712 abstract "Alzheimer's disease (AD) is an incapacitating neurodegenerative disease that slowly destroys brain cells. This disease progressively compromises both memory and cognition, culminating in a state of full dependence and dementia. Currently, AD is the main cause of dementia in the elderly and its prevalence in the developed world is increasing rapidly. Classic drugs, such as acetylcholinesterase inhibitors (AChEIs), fail to decline disease progression and display several side effects that reduce patient's adhesion to pharmacotherapy. The past decade has witnessed an increasing focus on the search for novel AChEIs and new putative enzymatic targets for AD, like β- and γ-secretases, sirtuins, caspase proteins and glycogen synthase kinase-3 (GSK-3). In addition, new mechanistic rationales for drug discovery in AD that include autophagy and synaptogenesis have been discovered. Herein, we describe the state-of-the-art of the development of recent enzymatic inhibitors and enhancers with therapeutic potential on the treatment of AD." @default.
- W2072156712 created "2016-06-24" @default.
- W2072156712 creator A5004888817 @default.
- W2072156712 creator A5022591153 @default.
- W2072156712 creator A5048396749 @default.
- W2072156712 creator A5068000809 @default.
- W2072156712 date "2014-05-01" @default.
- W2072156712 modified "2023-09-23" @default.
- W2072156712 title "Alzheimer's disease, enzyme targets and drug discovery struggles: From natural products to drug prototypes" @default.
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