Matches in SemOpenAlex for { <https://semopenalex.org/work/W2072156798> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2072156798 endingPage "74" @default.
- W2072156798 startingPage "67" @default.
- W2072156798 abstract "Following our recent finding that calmodulin antagonists can reduce cancer cell attachment to extracellular matrix proteins, we investigated the calmodulin antagonistic and anti-attachment properties of the non-steroidal anti-oestrogens tamoxifen and droloxifene. These drugs and four of their active metabolites were found to have calmodulin antagonist activity with IC50 values of 2-4 microM and to be capable of inhibiting attachment of murine B16 melanoma to extracellular matrix proteins in vitro. IC50 values for inhibition of attachment were 11 microM for tamoxifen and ranged from 5 to 40 microM for the other five compounds tested. (Poor reproducibility in drug potency between attachment experiments was almost certainly due to the low aqueous solubility of these drugs.) The effects of tamoxifen on cell/matrix adhesion were most evident between 15 min and 3 h of cell attachment. No effects of tamoxifen were evident in cells which had been allowed to attach for 6 h or more. Tamoxifen at concentrations between 0.1 and 30 microM was without effect on intracellular free calcium concentration. Tamoxifen also inhibited attachment of human ocular melanoma cells and human breast cancer (MCF7) cells to type I collagen. The concentration at which tamoxifen and its metabolites affect cell attachment in vitro (2-14 microM) is of the same order as the tissue concentrations of these drugs achieved clinically. The possibility exists that reduction of cell/matrix interactions may contribute to the clinical anti-metastatic efficacy of tamoxifen and some of its active metabolites." @default.
- W2072156798 created "2016-06-24" @default.
- W2072156798 creator A5014124622 @default.
- W2072156798 creator A5038602713 @default.
- W2072156798 creator A5047741365 @default.
- W2072156798 creator A5065621235 @default.
- W2072156798 creator A5069278976 @default.
- W2072156798 creator A5072439369 @default.
- W2072156798 creator A5077268376 @default.
- W2072156798 date "1993-04-01" @default.
- W2072156798 modified "2023-09-25" @default.
- W2072156798 title "Inhibition of melanoma cell/matrix interaction by tamoxifen" @default.
- W2072156798 doi "https://doi.org/10.1097/00008390-199304000-00010" @default.
- W2072156798 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8471839" @default.
- W2072156798 hasPublicationYear "1993" @default.
- W2072156798 type Work @default.
- W2072156798 sameAs 2072156798 @default.
- W2072156798 citedByCount "22" @default.
- W2072156798 countsByYear W20721567982014 @default.
- W2072156798 countsByYear W20721567982015 @default.
- W2072156798 countsByYear W20721567982017 @default.
- W2072156798 countsByYear W20721567982020 @default.
- W2072156798 crossrefType "journal-article" @default.
- W2072156798 hasAuthorship W2072156798A5014124622 @default.
- W2072156798 hasAuthorship W2072156798A5038602713 @default.
- W2072156798 hasAuthorship W2072156798A5047741365 @default.
- W2072156798 hasAuthorship W2072156798A5065621235 @default.
- W2072156798 hasAuthorship W2072156798A5069278976 @default.
- W2072156798 hasAuthorship W2072156798A5072439369 @default.
- W2072156798 hasAuthorship W2072156798A5077268376 @default.
- W2072156798 hasConcept C121608353 @default.
- W2072156798 hasConcept C126322002 @default.
- W2072156798 hasConcept C1491633281 @default.
- W2072156798 hasConcept C185592680 @default.
- W2072156798 hasConcept C189165786 @default.
- W2072156798 hasConcept C202751555 @default.
- W2072156798 hasConcept C2777176818 @default.
- W2072156798 hasConcept C2777752497 @default.
- W2072156798 hasConcept C28406088 @default.
- W2072156798 hasConcept C530470458 @default.
- W2072156798 hasConcept C54355233 @default.
- W2072156798 hasConcept C55493867 @default.
- W2072156798 hasConcept C71924100 @default.
- W2072156798 hasConcept C81885089 @default.
- W2072156798 hasConcept C86803240 @default.
- W2072156798 hasConcept C96232424 @default.
- W2072156798 hasConcept C98274493 @default.
- W2072156798 hasConceptScore W2072156798C121608353 @default.
- W2072156798 hasConceptScore W2072156798C126322002 @default.
- W2072156798 hasConceptScore W2072156798C1491633281 @default.
- W2072156798 hasConceptScore W2072156798C185592680 @default.
- W2072156798 hasConceptScore W2072156798C189165786 @default.
- W2072156798 hasConceptScore W2072156798C202751555 @default.
- W2072156798 hasConceptScore W2072156798C2777176818 @default.
- W2072156798 hasConceptScore W2072156798C2777752497 @default.
- W2072156798 hasConceptScore W2072156798C28406088 @default.
- W2072156798 hasConceptScore W2072156798C530470458 @default.
- W2072156798 hasConceptScore W2072156798C54355233 @default.
- W2072156798 hasConceptScore W2072156798C55493867 @default.
- W2072156798 hasConceptScore W2072156798C71924100 @default.
- W2072156798 hasConceptScore W2072156798C81885089 @default.
- W2072156798 hasConceptScore W2072156798C86803240 @default.
- W2072156798 hasConceptScore W2072156798C96232424 @default.
- W2072156798 hasConceptScore W2072156798C98274493 @default.
- W2072156798 hasIssue "1" @default.
- W2072156798 hasLocation W20721567981 @default.
- W2072156798 hasLocation W20721567982 @default.
- W2072156798 hasOpenAccess W2072156798 @default.
- W2072156798 hasPrimaryLocation W20721567981 @default.
- W2072156798 hasRelatedWork W1675599972 @default.
- W2072156798 hasRelatedWork W2010018045 @default.
- W2072156798 hasRelatedWork W2014734082 @default.
- W2072156798 hasRelatedWork W2032798840 @default.
- W2072156798 hasRelatedWork W2088551093 @default.
- W2072156798 hasRelatedWork W2290011309 @default.
- W2072156798 hasRelatedWork W2781098008 @default.
- W2072156798 hasRelatedWork W2914526697 @default.
- W2072156798 hasRelatedWork W3169834474 @default.
- W2072156798 hasRelatedWork W4301190239 @default.
- W2072156798 hasVolume "3" @default.
- W2072156798 isParatext "false" @default.
- W2072156798 isRetracted "false" @default.
- W2072156798 magId "2072156798" @default.
- W2072156798 workType "article" @default.