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- W2072173806 abstract "Calcineurin inhibitor induced thrombotic microangiopathy is a rare but well recognized complication of a renal transplantation that occurs in 1% of the patients who are on tacrolimus immunosuppression. Among the other aetiological factors of the de-novo Thrombotic Microangiopathy (TMA), the condition especially has to be differentiated from an antibody mediated rejection, as both have different pathogenesis, therapeutic connotations and outcomes.We report a case of a middle aged female renal transplant recipient treated with tacrolimus, who developed localised thrombotic microangiopathy in the early post transplantation period. Despite the normal trough levels of tacrolimus, a diagnosis of Tacrolimus induced TMA was rendered after excluding other causes of the de-novo TMA, which included an antibody mediated rejection, a meticulous clinico-pathological correlation and serological studies. The treatment included the substitution of tacrolimus by rapamycin, with the subsequent normalization of the renal function." @default.
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- W2072173806 date "2012-01-01" @default.
- W2072173806 modified "2023-09-27" @default.
- W2072173806 title "Tacrolimus Associated Localized Thrombotic Microangiopathy Developing in Early Stage after Renal Transplantation" @default.
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- W2072173806 doi "https://doi.org/10.7860/jcdr/2012/4535.2614" @default.
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