FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2072178488> ?p ?o ?g. }

• W2072178488 endingPage "932" @default.
• W2072178488 startingPage "923" @default.
• W2072178488 abstract "In order to find new peptide inhibitors for voltage-dependent potassium (Kv) channels, we examined the effects of venom from Theraphosa leblondi on Kv channel-mediated currents with the whole-cell patch-clamp technique. Both A-type currents in cultured hippocampal neurons and A-type currents recorded from HEK 293 cells transiently expressing recombinant Kv4.2 channels were selectively inhibited by T. leblondi venom. No venom activity was observed on recombinant Kv1.3, Kv1.4, Kv2.1 or Kv3.4 channels. We purified and sequenced three novel homologous peptides from this venom, which are related to previously identified Kv4 channel-specific peptide inhibitors and were named T. leblondi toxin (TLTx) 1, 2 and 3. The mode of action of TLTx1 on recombinant Kv4.2 channels was studied in more detail. TLTx1 inhibited Kv4.2-mediated currents with an IC50 of ∼200 nM, and macroscopic current inactivation was slowed in the presence of TLTx1. Notably, TLTx1 also caused a shallower voltage dependence of Kv4.2 peak conductance and a shift of the activation midpoint to more positive potentials (ΔV1/2=+35mV). TLTx1 caused a noticable slowing of Kv4.2 activation kinetics, and Kv4.2 deactivation kinetics were accelerated by TLTx1 as infered from Rb+ tail current measurements. Chimeric Kv2.1(4.2L3-4) channels, in which the linker region between S3 and S4 of the TLTx1-insensitive Kv2.1 channel was replaced by the corresponding Kv4.2 domain, were sensitive to TLTx1. Apparently, TLTx1 can act as a gating modifier of Kv4.2 channels." @default.
• W2072178488 created "2016-06-24" @default.
• W2072178488 creator A5009268676 @default.
• W2072178488 creator A5009318026 @default.
• W2072178488 creator A5010808592 @default.
• W2072178488 creator A5036430313 @default.
• W2072178488 creator A5055422451 @default.
• W2072178488 creator A5062329962 @default.
• W2072178488 creator A5071615457 @default.
• W2072178488 date "2004-06-01" @default.
• W2072178488 modified "2023-09-25" @default.
• W2072178488 title "Modulation of Kv4.2 channels by a peptide isolated from the venom of the giant bird-eating tarantula Theraphosa leblondi" @default.
• W2072178488 cites W1601172323 @default.
• W2072178488 cites W162296534 @default.
• W2072178488 cites W1954929088 @default.
• W2072178488 cites W1964774201 @default.
• W2072178488 cites W1966815375 @default.
• W2072178488 cites W1989736892 @default.
• W2072178488 cites W2008890525 @default.
• W2072178488 cites W2009667219 @default.
• W2072178488 cites W2020872723 @default.
• W2072178488 cites W2032137808 @default.
• W2072178488 cites W2032734987 @default.
• W2072178488 cites W2038375865 @default.
• W2072178488 cites W2039322570 @default.
• W2072178488 cites W2045882841 @default.
• W2072178488 cites W2054855795 @default.
• W2072178488 cites W2056961349 @default.
• W2072178488 cites W2075984436 @default.
• W2072178488 cites W2100548210 @default.
• W2072178488 cites W2100977476 @default.
• W2072178488 cites W2102006233 @default.
• W2072178488 cites W2106467520 @default.
• W2072178488 cites W2106670341 @default.
• W2072178488 cites W2127653973 @default.
• W2072178488 cites W2143070723 @default.
• W2072178488 cites W2404672629 @default.
• W2072178488 doi "https://doi.org/10.1016/j.toxicon.2003.12.012" @default.
• W2072178488 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15208026" @default.
• W2072178488 hasPublicationYear "2004" @default.
• W2072178488 type Work @default.
• W2072178488 sameAs 2072178488 @default.
• W2072178488 citedByCount "32" @default.
• W2072178488 countsByYear W20721784882012 @default.
• W2072178488 countsByYear W20721784882013 @default.
• W2072178488 countsByYear W20721784882015 @default.
• W2072178488 countsByYear W20721784882016 @default.
• W2072178488 countsByYear W20721784882017 @default.
• W2072178488 countsByYear W20721784882019 @default.
• W2072178488 countsByYear W20721784882020 @default.
• W2072178488 countsByYear W20721784882021 @default.
• W2072178488 crossrefType "journal-article" @default.
• W2072178488 hasAuthorship W2072178488A5009268676 @default.
• W2072178488 hasAuthorship W2072178488A5009318026 @default.
• W2072178488 hasAuthorship W2072178488A5010808592 @default.
• W2072178488 hasAuthorship W2072178488A5036430313 @default.
• W2072178488 hasAuthorship W2072178488A5055422451 @default.
• W2072178488 hasAuthorship W2072178488A5062329962 @default.
• W2072178488 hasAuthorship W2072178488A5071615457 @default.
• W2072178488 hasConcept C104317684 @default.
• W2072178488 hasConcept C121332964 @default.
• W2072178488 hasConcept C121932024 @default.
• W2072178488 hasConcept C12554922 @default.
• W2072178488 hasConcept C147944092 @default.
• W2072178488 hasConcept C169760540 @default.
• W2072178488 hasConcept C170493617 @default.
• W2072178488 hasConcept C174510640 @default.
• W2072178488 hasConcept C185263204 @default.
• W2072178488 hasConcept C185592680 @default.
• W2072178488 hasConcept C194544171 @default.
• W2072178488 hasConcept C26873012 @default.
• W2072178488 hasConcept C2776676993 @default.
• W2072178488 hasConcept C2777884321 @default.
• W2072178488 hasConcept C2779281246 @default.
• W2072178488 hasConcept C2779448229 @default.
• W2072178488 hasConcept C2910159647 @default.
• W2072178488 hasConcept C40767141 @default.
• W2072178488 hasConcept C55493867 @default.
• W2072178488 hasConcept C83743174 @default.
• W2072178488 hasConcept C86803240 @default.
• W2072178488 hasConceptScore W2072178488C104317684 @default.
• W2072178488 hasConceptScore W2072178488C121332964 @default.
• W2072178488 hasConceptScore W2072178488C121932024 @default.
• W2072178488 hasConceptScore W2072178488C12554922 @default.
• W2072178488 hasConceptScore W2072178488C147944092 @default.
• W2072178488 hasConceptScore W2072178488C169760540 @default.
• W2072178488 hasConceptScore W2072178488C170493617 @default.
• W2072178488 hasConceptScore W2072178488C174510640 @default.
• W2072178488 hasConceptScore W2072178488C185263204 @default.
• W2072178488 hasConceptScore W2072178488C185592680 @default.
• W2072178488 hasConceptScore W2072178488C194544171 @default.
• W2072178488 hasConceptScore W2072178488C26873012 @default.
• W2072178488 hasConceptScore W2072178488C2776676993 @default.
• W2072178488 hasConceptScore W2072178488C2777884321 @default.
• W2072178488 hasConceptScore W2072178488C2779281246 @default.
• W2072178488 hasConceptScore W2072178488C2779448229 @default.
• W2072178488 hasConceptScore W2072178488C2910159647 @default.
• W2072178488 hasConceptScore W2072178488C40767141 @default.

• next