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- W2072184430 abstract "Cholesterol and triglyceride levels and lipoprotein patterns have been investigated in 108 male and 85 female survivors of myocardial infarction. Lipid levels and the frequency of abnormal lipoprotein patterns have been compared with control values. 127 first-degree relatives of patients with hyperlipoproteinæmia have also been investigated. Cholesterol levels were most notably raised in the younger male patients and the older female patients. Triglyceride levels were most raised in both male and female patients in the fifth decade. Lipoprotein abnormalities were present in 22% of all the male patients and in 33% of all the female patients. In the younger age-groups, the frequency of type-II lipoprotein patterns was similar to the frequency of type-IV patterns, but there was an excess of type-II lipoprotein patterns among the older female patients. Lipoprotein abnormalities were present in 5% of male and 14% of female controls. Investigation of the first-degree relatives of the hyperlipidæmic patients showed an increase of mean cholesterol levels among the relatives of patients with type-II lipoprotein disturbance, but only a third of the index patients had a first-degree relative affected with the same disorder. The distribution of cholesterol levels among the relatives suggested that the type-II disturbance in the index patients was determined by the already known single gene of large effect in a minority and that the abnormality in the majority of index patients was multifactorially determined. The first-degree relatives of patients with type-IV hyperlipidæmia showed an increase in mean triglyceride levels, but the mode of inheritance of the type-IV abnormality is not yet known, and could not be deduced." @default.
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- W2072184430 date "1972-02-01" @default.
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- W2072184430 title "LIPID ABNORMALITIES IN MALE AND FEMALE SURVIVORS OF MYOCARDIAL INFARCTION AND THEIR FIRST-DEGREE RELATIVES" @default.
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- W2072184430 doi "https://doi.org/10.1016/s0140-6736(72)90853-7" @default.
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