FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2072194297> ?p ?o ?g. }

• W2072194297 endingPage "8701" @default.
• W2072194297 startingPage "8687" @default.
• W2072194297 abstract "Targeted delivery of vaccine candidates to the gastrointestinal (GI) tract holds potential for mucosal immunization, particularly against mucosal pathogens like the human immunodeficiency virus (HIV). Among the different strategies for achieving targeted release in the GI tract, namely the small intestine, pH sensitive enteric coating polymers have been shown to protect solid oral dosage forms from the harsh digestive environment of the stomach and dissolve relatively rapidly in the small intestine by taking advantage of the luminal pH gradient. We developed an enteric polymethacrylate formulation for coating hydroxy-propyl-methyl-cellulose (HPMC) capsules containing lyophilized Adenoviral type 5 (Ad5) vectors expressing HIV-1 gag and a string of six highly-conserved HIV-1 envelope peptides representing broadly cross-reactive CD4+ and CD8+ T cell epitopes. Oral immunization of rhesus macaques with these capsules primed antigen-specific mucosal and systemic immune responses and subsequent intranasal delivery of the envelope peptide cocktail using a mutant cholera toxin adjuvant boosted cellular immune responses including, antigen-specific intracellular IFN-γ-producing CD4+ and CD8+ effector memory T cells in the intestine. These results suggest that the combination of oral adenoviral vector priming followed by intranasal protein/peptide boosting may be an effective mucosal HIV vaccination strategy for targeting viral antigens to the GI tract and priming systemic and mucosal immunity." @default.
• W2072194297 created "2016-06-24" @default.
• W2072194297 creator A5006278490 @default.
• W2072194297 creator A5007076967 @default.
• W2072194297 creator A5034754268 @default.
• W2072194297 creator A5038887071 @default.
• W2072194297 creator A5045130132 @default.
• W2072194297 creator A5066578479 @default.
• W2072194297 creator A5068870333 @default.
• W2072194297 creator A5073092010 @default.
• W2072194297 creator A5078671269 @default.
• W2072194297 creator A5090461014 @default.
• W2072194297 date "2007-12-01" @default.
• W2072194297 modified "2023-10-17" @default.
• W2072194297 title "Oral immunization of rhesus macaques with adenoviral HIV vaccines using enteric-coated capsules" @default.
• W2072194297 cites W104910540 @default.
• W2072194297 cites W1504335832 @default.
• W2072194297 cites W1549826455 @default.
• W2072194297 cites W1590390236 @default.
• W2072194297 cites W1615827568 @default.
• W2072194297 cites W1698490607 @default.
• W2072194297 cites W1924636867 @default.
• W2072194297 cites W1942111290 @default.
• W2072194297 cites W1973539060 @default.
• W2072194297 cites W1977799018 @default.
• W2072194297 cites W1980624354 @default.
• W2072194297 cites W1986857394 @default.
• W2072194297 cites W1989952695 @default.
• W2072194297 cites W2001607283 @default.
• W2072194297 cites W2001714357 @default.
• W2072194297 cites W2012709324 @default.
• W2072194297 cites W2013716020 @default.
• W2072194297 cites W2016071978 @default.
• W2072194297 cites W2016296837 @default.
• W2072194297 cites W2018445772 @default.
• W2072194297 cites W2020982853 @default.
• W2072194297 cites W2024301353 @default.
• W2072194297 cites W2026223457 @default.
• W2072194297 cites W2027705515 @default.
• W2072194297 cites W2032755224 @default.
• W2072194297 cites W2041245874 @default.
• W2072194297 cites W2045047851 @default.
• W2072194297 cites W2054261154 @default.
• W2072194297 cites W2056165168 @default.
• W2072194297 cites W2060044832 @default.
• W2072194297 cites W2060125490 @default.
• W2072194297 cites W2062878441 @default.
• W2072194297 cites W2066763944 @default.
• W2072194297 cites W2072124849 @default.
• W2072194297 cites W2075183351 @default.
• W2072194297 cites W2078116888 @default.
• W2072194297 cites W2078218002 @default.
• W2072194297 cites W2078224833 @default.
• W2072194297 cites W2080552478 @default.
• W2072194297 cites W2082787868 @default.
• W2072194297 cites W2089504473 @default.
• W2072194297 cites W2091570574 @default.
• W2072194297 cites W2092473610 @default.
• W2072194297 cites W2093088755 @default.
• W2072194297 cites W2099291490 @default.
• W2072194297 cites W2102084617 @default.
• W2072194297 cites W2102360506 @default.
• W2072194297 cites W2108838669 @default.
• W2072194297 cites W2112336067 @default.
• W2072194297 cites W2127346850 @default.
• W2072194297 cites W2148123079 @default.
• W2072194297 cites W2149903437 @default.
• W2072194297 cites W2150086993 @default.
• W2072194297 cites W2155657105 @default.
• W2072194297 cites W2156096124 @default.
• W2072194297 cites W2158255509 @default.
• W2072194297 cites W2161344127 @default.
• W2072194297 cites W2316528098 @default.
• W2072194297 cites W4237459134 @default.
• W2072194297 doi "https://doi.org/10.1016/j.vaccine.2007.10.030" @default.
• W2072194297 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2225545" @default.
• W2072194297 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18063450" @default.
• W2072194297 hasPublicationYear "2007" @default.
• W2072194297 type Work @default.
• W2072194297 sameAs 2072194297 @default.
• W2072194297 citedByCount "49" @default.
• W2072194297 countsByYear W20721942972012 @default.
• W2072194297 countsByYear W20721942972013 @default.
• W2072194297 countsByYear W20721942972014 @default.
• W2072194297 countsByYear W20721942972015 @default.
• W2072194297 countsByYear W20721942972016 @default.
• W2072194297 countsByYear W20721942972017 @default.
• W2072194297 countsByYear W20721942972018 @default.
• W2072194297 countsByYear W20721942972019 @default.
• W2072194297 countsByYear W20721942972020 @default.
• W2072194297 crossrefType "journal-article" @default.
• W2072194297 hasAuthorship W2072194297A5006278490 @default.
• W2072194297 hasAuthorship W2072194297A5007076967 @default.
• W2072194297 hasAuthorship W2072194297A5034754268 @default.
• W2072194297 hasAuthorship W2072194297A5038887071 @default.
• W2072194297 hasAuthorship W2072194297A5045130132 @default.
• W2072194297 hasAuthorship W2072194297A5066578479 @default.
• W2072194297 hasAuthorship W2072194297A5068870333 @default.

• next