FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2072201354> ?p ?o ?g. }

• W2072201354 endingPage "328" @default.
• W2072201354 startingPage "316" @default.
• W2072201354 abstract "Abstract Interaction of insulin‐like growth factor receptor I (IGF‐IR) with its ligands has been reported to induce cell proliferation, transformation and blockade of cell apoptotic functions. IGF‐IR is overexpressed on numerous tumor cell types and its blockade could be of importance for anti‐cancer therapy. We have generated a humanized anti‐IGF‐IR antibody h7C10 that blocks in vitro IGF‐I and IGF‐II‐induced cell proliferation of MCF‐7 breast cancer cells. Analysis of the IGF‐I transduction cascade demonstrated that the humanized anti‐IGF‐IR antibody and its murine parental form block IGF‐I‐induced tyrosine phosphorylation, both its β‐chain and IRS‐1 tyrosine phosphorylation. This presumably leads to cell cycle arrest and, consequently, growth inhibition. Treatment of nude mice bearing either human breast cancer cells (MCF‐7) or non small lung cancer cells (A549) with h7C10, or its murine parental form 7C10, inhibited significantly tumor growth. An almost complete inhibition of A549 tumor growth was observed when mice were treated with the anti‐IGF‐IR antibody combined with either a chemotherapeutic agent, Vinorelbine or an anti‐epidermal growth factor receptor (EGFR) antibody, 225. Combined therapy prolonged significantly the life span of mice in an orthotopic in vivo model of A549; the combination of the anti‐IGF‐IR antibody with an anti‐EGFR antibody was superior to the Vinorelbine combination. The present results indicate that the humanized anti‐IGF‐IR antibody h7C10 has a great potential for cancer therapy when combined with either a chemotherapeutic agent or an antibody that targets other growth factor receptors, such as the epidermal growth factor receptor." @default.
• W2072201354 created "2016-06-24" @default.
• W2072201354 creator A5012102083 @default.
• W2072201354 creator A5028729389 @default.
• W2072201354 creator A5035474484 @default.
• W2072201354 creator A5040900281 @default.
• W2072201354 creator A5052561639 @default.
• W2072201354 creator A5067074161 @default.
• W2072201354 creator A5076263638 @default.
• W2072201354 date "2004-08-25" @default.
• W2072201354 modified "2023-10-17" @default.
• W2072201354 title "A recombinant humanized anti-insulin-like growth factor receptor type I antibody (h7C10) enhances the antitumor activity of vinorelbine and anti-epidermal growth factor receptor therapy against human cancer xenografts" @default.
• W2072201354 cites W1499890190 @default.
• W2072201354 cites W1536119619 @default.
• W2072201354 cites W1591360311 @default.
• W2072201354 cites W1634064292 @default.
• W2072201354 cites W1824970382 @default.
• W2072201354 cites W1931843124 @default.
• W2072201354 cites W1954313480 @default.
• W2072201354 cites W1969703241 @default.
• W2072201354 cites W1969835546 @default.
• W2072201354 cites W1969898679 @default.
• W2072201354 cites W1970285990 @default.
• W2072201354 cites W1981661908 @default.
• W2072201354 cites W1991397526 @default.
• W2072201354 cites W1994100210 @default.
• W2072201354 cites W1995782933 @default.
• W2072201354 cites W1995862047 @default.
• W2072201354 cites W1998149673 @default.
• W2072201354 cites W1998961381 @default.
• W2072201354 cites W2006754781 @default.
• W2072201354 cites W2011940682 @default.
• W2072201354 cites W2012940389 @default.
• W2072201354 cites W2013523350 @default.
• W2072201354 cites W2013932846 @default.
• W2072201354 cites W2014564257 @default.
• W2072201354 cites W2015993358 @default.
• W2072201354 cites W2017949036 @default.
• W2072201354 cites W2020809609 @default.
• W2072201354 cites W2021730962 @default.
• W2072201354 cites W2032144081 @default.
• W2072201354 cites W2040961694 @default.
• W2072201354 cites W2042268825 @default.
• W2072201354 cites W2044311605 @default.
• W2072201354 cites W2057458801 @default.
• W2072201354 cites W2058691287 @default.
• W2072201354 cites W2062468721 @default.
• W2072201354 cites W2064684365 @default.
• W2072201354 cites W2065768124 @default.
• W2072201354 cites W2070284356 @default.
• W2072201354 cites W2072246040 @default.
• W2072201354 cites W2081948388 @default.
• W2072201354 cites W2085490118 @default.
• W2072201354 cites W2085974978 @default.
• W2072201354 cites W2087729478 @default.
• W2072201354 cites W2088145632 @default.
• W2072201354 cites W2090192769 @default.
• W2072201354 cites W2093153734 @default.
• W2072201354 cites W2093595415 @default.
• W2072201354 cites W2098544382 @default.
• W2072201354 cites W2128746359 @default.
• W2072201354 cites W2160466713 @default.
• W2072201354 cites W2166299099 @default.
• W2072201354 cites W2171298883 @default.
• W2072201354 cites W2275727528 @default.
• W2072201354 cites W4237186569 @default.
• W2072201354 cites W4237585679 @default.
• W2072201354 doi "https://doi.org/10.1002/ijc.20543" @default.
• W2072201354 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15386423" @default.
• W2072201354 hasPublicationYear "2004" @default.
• W2072201354 type Work @default.
• W2072201354 sameAs 2072201354 @default.
• W2072201354 citedByCount "201" @default.
• W2072201354 countsByYear W20722013542012 @default.
• W2072201354 countsByYear W20722013542013 @default.
• W2072201354 countsByYear W20722013542014 @default.
• W2072201354 countsByYear W20722013542015 @default.
• W2072201354 countsByYear W20722013542016 @default.
• W2072201354 countsByYear W20722013542017 @default.
• W2072201354 countsByYear W20722013542018 @default.
• W2072201354 countsByYear W20722013542019 @default.
• W2072201354 countsByYear W20722013542020 @default.
• W2072201354 countsByYear W20722013542021 @default.
• W2072201354 crossrefType "journal-article" @default.
• W2072201354 hasAuthorship W2072201354A5012102083 @default.
• W2072201354 hasAuthorship W2072201354A5028729389 @default.
• W2072201354 hasAuthorship W2072201354A5035474484 @default.
• W2072201354 hasAuthorship W2072201354A5040900281 @default.
• W2072201354 hasAuthorship W2072201354A5052561639 @default.
• W2072201354 hasAuthorship W2072201354A5067074161 @default.
• W2072201354 hasAuthorship W2072201354A5076263638 @default.
• W2072201354 hasBestOaLocation W20722013541 @default.
• W2072201354 hasConcept C121608353 @default.
• W2072201354 hasConcept C126322002 @default.
• W2072201354 hasConcept C159654299 @default.
• W2072201354 hasConcept C170493617 @default.
• W2072201354 hasConcept C203014093 @default.
• W2072201354 hasConcept C26375932 @default.

• next