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• W2072208433 abstract "The reaction of the five-membered C,N-palladacycle [(L)PdCl](2), where LH = 1-methyl-5-phenyl-1H-1,4-benzodiazepin-2(3H)-one, with 1,2-ethanebis(diphenylphosphine), dppe, leads to the formation of the bridged palladacycle. [Pd(2)L(2)(mu-dppe)Cl(2)] 3, which was characterised in solution by (1)H and (31)P NMR spectroscopy and in the solid state by X-ray crystallography. Complex 3 was tested in vitro against a number of cell lines. For example, it inhibited K562 leukaemia cells with an IC(50) value of 4.3 microM (1 h exposure) and displayed cathepsin B inhibitory action with an IC(50) value of 3 microM." @default.
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• W2072208433 date "2009-01-01" @default.
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• W2072208433 title "Synthesis of a 1,4-benzodiazepine containing palladacycle with in vitro anticancer and cathepsin B activity" @default.
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• W2072208433 doi "https://doi.org/10.1039/b819061e" @default.
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