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• W2072213636 endingPage "145" @default.
• W2072213636 startingPage "104" @default.
• W2072213636 abstract "Identification of the primary products of cyclo-oxygenase (COX)/prostaglandin synthase(s), which occurred between 1958 and 1976, was followed by a classification system for prostanoid receptors (DP, EP(1), EP(2) ...) based mainly on the pharmacological actions of natural and synthetic agonists and a few antagonists. The design of potent selective antagonists was rapid for certain prostanoid receptors (EP(1), TP), slow for others (FP, IP) and has yet to be achieved in certain cases (EP(2)). While some antagonists are structurally related to the natural agonist, most recent compounds are 'non-prostanoid' (often acyl-sulphonamides) and have emerged from high-throughput screening of compound libraries, made possible by the development of (functional) assays involving single recombinant prostanoid receptors. Selective antagonists have been crucial to defining the roles of PGD(2) (acting on DP(1) and DP(2) receptors) and PGE(2) (on EP(1) and EP(4) receptors) in various inflammatory conditions; there are clear opportunities for therapeutic intervention. The vast endeavour on TP (thromboxane) antagonists is considered in relation to their limited pharmaceutical success in the cardiovascular area. Correspondingly, the clinical utility of IP (prostacyclin) antagonists is assessed in relation to the cloud hanging over the long-term safety of selective COX-2 inhibitors. Aspirin apart, COX inhibitors broadly suppress all prostanoid pathways, while high selectivity has been a major goal in receptor antagonist development; more targeted therapy may require an intermediate position with defined antagonist selectivity profiles. This review is intended to provide overviews of each antagonist class (including prostamide antagonists), covering major development strategies and current and potential clinical usage." @default.
• W2072213636 created "2016-06-24" @default.
• W2072213636 creator A5002946130 @default.
• W2072213636 creator A5054192257 @default.
• W2072213636 creator A5091203059 @default.
• W2072213636 date "2009-08-25" @default.
• W2072213636 modified "2023-09-24" @default.
• W2072213636 title "Prostanoid receptor antagonists: development strategies and therapeutic applications" @default.
• W2072213636 cites W103769008 @default.
• W2072213636 cites W1481564277 @default.
• W2072213636 cites W1483555207 @default.
• W2072213636 cites W149875176 @default.
• W2072213636 cites W1511725315 @default.
• W2072213636 cites W1519407136 @default.
• W2072213636 cites W1525044292 @default.
• W2072213636 cites W1533085687 @default.
• W2072213636 cites W1542045064 @default.
• W2072213636 cites W1543776771 @default.
• W2072213636 cites W1557741015 @default.
• W2072213636 cites W1565847282 @default.
• W2072213636 cites W1597162209 @default.
• W2072213636 cites W1640144340 @default.
• W2072213636 cites W1647648618 @default.
• W2072213636 cites W1666619344 @default.
• W2072213636 cites W1680932833 @default.
• W2072213636 cites W1779958125 @default.
• W2072213636 cites W1802267091 @default.
• W2072213636 cites W1846149196 @default.
• W2072213636 cites W1855282862 @default.
• W2072213636 cites W1948702918 @default.
• W2072213636 cites W1963212659 @default.
• W2072213636 cites W1965847104 @default.
• W2072213636 cites W1965970483 @default.
• W2072213636 cites W1966204653 @default.
• W2072213636 cites W1967022231 @default.
• W2072213636 cites W1967101173 @default.
• W2072213636 cites W1967678975 @default.
• W2072213636 cites W1969627458 @default.
• W2072213636 cites W1970225983 @default.
• W2072213636 cites W1970980292 @default.
• W2072213636 cites W1971564993 @default.
• W2072213636 cites W1972153352 @default.
• W2072213636 cites W1972202896 @default.
• W2072213636 cites W1972289296 @default.
• W2072213636 cites W1972345417 @default.
• W2072213636 cites W1972995848 @default.
• W2072213636 cites W1973617905 @default.
• W2072213636 cites W1973781208 @default.
• W2072213636 cites W1974451559 @default.
• W2072213636 cites W1975158600 @default.
• W2072213636 cites W1975402623 @default.
• W2072213636 cites W1976162981 @default.
• W2072213636 cites W1976234470 @default.
• W2072213636 cites W1977711557 @default.
• W2072213636 cites W1978331182 @default.
• W2072213636 cites W1978804708 @default.
• W2072213636 cites W1979581142 @default.
• W2072213636 cites W1979903655 @default.
• W2072213636 cites W1980109320 @default.
• W2072213636 cites W1981292116 @default.
• W2072213636 cites W1981729318 @default.
• W2072213636 cites W1983370454 @default.
• W2072213636 cites W1984166776 @default.
• W2072213636 cites W1984265477 @default.
• W2072213636 cites W1984413846 @default.
• W2072213636 cites W1985221337 @default.
• W2072213636 cites W1985780560 @default.
• W2072213636 cites W1985832778 @default.
• W2072213636 cites W1986274336 @default.
• W2072213636 cites W1986634935 @default.
• W2072213636 cites W1987268939 @default.
• W2072213636 cites W1987641397 @default.
• W2072213636 cites W1988164713 @default.
• W2072213636 cites W1990007488 @default.
• W2072213636 cites W1990046688 @default.
• W2072213636 cites W1990264134 @default.
• W2072213636 cites W1990473701 @default.
• W2072213636 cites W1990563051 @default.
• W2072213636 cites W1990865851 @default.
• W2072213636 cites W1991108239 @default.
• W2072213636 cites W1991238781 @default.
• W2072213636 cites W1991266606 @default.
• W2072213636 cites W1991702914 @default.
• W2072213636 cites W1992046153 @default.
• W2072213636 cites W1992267298 @default.
• W2072213636 cites W1992548164 @default.
• W2072213636 cites W1992648456 @default.
• W2072213636 cites W1992901272 @default.
• W2072213636 cites W1992912127 @default.
• W2072213636 cites W1993823998 @default.
• W2072213636 cites W1994424025 @default.
• W2072213636 cites W1994518885 @default.
• W2072213636 cites W1994679263 @default.
• W2072213636 cites W1996042725 @default.
• W2072213636 cites W1997997155 @default.
• W2072213636 cites W1998400972 @default.
• W2072213636 cites W1998436891 @default.
• W2072213636 cites W1998521301 @default.

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