Matches in SemOpenAlex for { <https://semopenalex.org/work/W2072214054> ?p ?o ?g. }
- W2072214054 endingPage "671" @default.
- W2072214054 startingPage "663" @default.
- W2072214054 abstract "Aristolochic acid (AA), derived from the Aristolochia species, has been associated with aristolochic acid nephropathy (AAN), which has emerged as a worldwide disease. Aristolochic acid I (AAI) is the main ingredient of AA, and the underlying mechanisms for AAI-induced nephrotoxicity are still unclear. In this study, we investigated whether endoplasmic reticulum (ER) stress was involved in AAI-induced nephrotoxicity. The results showed that treatment of HK-2 cells (a human proximal tubular epithelial cell line) with AAI caused an increase in eukaryotic initiation factor-2α (eIF2α) phosphorylation, X-box binding protein 1 (XBP1) mRNA splicing and the expression of glucose-regulated protein (GRP) 78 and CAAT/enhancer-binding protein-homologous protein (CHOP). These events represent typical markers of the ER stress-related signaling pathway. Pretreatment with 4-phenylbutyrate (4-PBA) or salubrinal (Sal) significantly inhibited AAI-induced apoptosis, indicating the role of ER stress in AAI-induced apoptosis. In addition, AAI-induced cell death followed an increase of reactive oxygen species (ROS) formation in HK-2 cells. Pretreatment with N-acetyl cysteine (NAC) or glutathione (GSH) significantly inhibited AAI-induced ER stress proteins and cell death, suggesting that ROS mediate AAI-induced ER stress. Taken together, these results suggest that the ER stress response is involved in apoptosis induced by AAI in HK-2 cells, thus offering a new insight into the nephrotoxicity of AAI." @default.
- W2072214054 created "2016-06-24" @default.
- W2072214054 creator A5003642180 @default.
- W2072214054 creator A5008772470 @default.
- W2072214054 creator A5009884211 @default.
- W2072214054 creator A5025277732 @default.
- W2072214054 creator A5027649946 @default.
- W2072214054 creator A5063083521 @default.
- W2072214054 creator A5065479590 @default.
- W2072214054 creator A5074905951 @default.
- W2072214054 creator A5081594780 @default.
- W2072214054 creator A5082156574 @default.
- W2072214054 creator A5086817506 @default.
- W2072214054 date "2012-08-01" @default.
- W2072214054 modified "2023-10-17" @default.
- W2072214054 title "Endoplasmic reticulum stress mediates aristolochic acid I-induced apoptosis in human renal proximal tubular epithelial cells" @default.
- W2072214054 cites W1570888466 @default.
- W2072214054 cites W1966364554 @default.
- W2072214054 cites W1971613226 @default.
- W2072214054 cites W1976161806 @default.
- W2072214054 cites W1983071035 @default.
- W2072214054 cites W2000066370 @default.
- W2072214054 cites W2012792172 @default.
- W2072214054 cites W2018086514 @default.
- W2072214054 cites W2024445551 @default.
- W2072214054 cites W2024901915 @default.
- W2072214054 cites W2025511820 @default.
- W2072214054 cites W2028524030 @default.
- W2072214054 cites W2033089404 @default.
- W2072214054 cites W2037673603 @default.
- W2072214054 cites W2045318949 @default.
- W2072214054 cites W2048456744 @default.
- W2072214054 cites W2049234564 @default.
- W2072214054 cites W2057389679 @default.
- W2072214054 cites W2065638130 @default.
- W2072214054 cites W2077122464 @default.
- W2072214054 cites W2081690197 @default.
- W2072214054 cites W2082503951 @default.
- W2072214054 cites W2083278580 @default.
- W2072214054 cites W2088181825 @default.
- W2072214054 cites W2089198803 @default.
- W2072214054 cites W2089521856 @default.
- W2072214054 cites W2093526428 @default.
- W2072214054 cites W2100204093 @default.
- W2072214054 cites W2101049762 @default.
- W2072214054 cites W2120221084 @default.
- W2072214054 cites W2120736516 @default.
- W2072214054 cites W2130326770 @default.
- W2072214054 cites W2140487984 @default.
- W2072214054 cites W2143882807 @default.
- W2072214054 cites W2144065739 @default.
- W2072214054 cites W2144320763 @default.
- W2072214054 cites W2148125367 @default.
- W2072214054 cites W2160162572 @default.
- W2072214054 cites W2167361106 @default.
- W2072214054 doi "https://doi.org/10.1016/j.tiv.2012.03.005" @default.
- W2072214054 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22445861" @default.
- W2072214054 hasPublicationYear "2012" @default.
- W2072214054 type Work @default.
- W2072214054 sameAs 2072214054 @default.
- W2072214054 citedByCount "40" @default.
- W2072214054 countsByYear W20722140542012 @default.
- W2072214054 countsByYear W20722140542013 @default.
- W2072214054 countsByYear W20722140542014 @default.
- W2072214054 countsByYear W20722140542015 @default.
- W2072214054 countsByYear W20722140542016 @default.
- W2072214054 countsByYear W20722140542018 @default.
- W2072214054 countsByYear W20722140542019 @default.
- W2072214054 countsByYear W20722140542020 @default.
- W2072214054 countsByYear W20722140542021 @default.
- W2072214054 countsByYear W20722140542022 @default.
- W2072214054 countsByYear W20722140542023 @default.
- W2072214054 crossrefType "journal-article" @default.
- W2072214054 hasAuthorship W2072214054A5003642180 @default.
- W2072214054 hasAuthorship W2072214054A5008772470 @default.
- W2072214054 hasAuthorship W2072214054A5009884211 @default.
- W2072214054 hasAuthorship W2072214054A5025277732 @default.
- W2072214054 hasAuthorship W2072214054A5027649946 @default.
- W2072214054 hasAuthorship W2072214054A5063083521 @default.
- W2072214054 hasAuthorship W2072214054A5065479590 @default.
- W2072214054 hasAuthorship W2072214054A5074905951 @default.
- W2072214054 hasAuthorship W2072214054A5081594780 @default.
- W2072214054 hasAuthorship W2072214054A5082156574 @default.
- W2072214054 hasAuthorship W2072214054A5086817506 @default.
- W2072214054 hasConcept C104317684 @default.
- W2072214054 hasConcept C126189478 @default.
- W2072214054 hasConcept C134018914 @default.
- W2072214054 hasConcept C139447449 @default.
- W2072214054 hasConcept C158617107 @default.
- W2072214054 hasConcept C185592680 @default.
- W2072214054 hasConcept C190283241 @default.
- W2072214054 hasConcept C2776151105 @default.
- W2072214054 hasConcept C2780091579 @default.
- W2072214054 hasConcept C2780813843 @default.
- W2072214054 hasConcept C2781331208 @default.
- W2072214054 hasConcept C31573885 @default.
- W2072214054 hasConcept C48349386 @default.
- W2072214054 hasConcept C54355233 @default.