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- W2072214145 abstract "Abstract The general pharmacologic and toxicologic characteristics of a new central depressant compound, 3-(1,2,3,4-tetrahydro-7-naphthyloxy)-2-hydroxypropyl carbamate (TNPC), were compared with those of meprobamate and chloridazepoxide as reference drugs. 1. 1. Oral LD 50 and PD 50 administrations of TNPC were >5000 mg/kg and 1450 mg/kg, respectively. 2. 2. TNPC demonstrated a potent anticonvulsant property against electroshock and chemoshock produced by picrotoxin, strychnine, or pentylenetetrazol. 3. 3. In mice inhibitory actions of TNPC were observed on spontaneous motor activity, fighting episodes, and the stimulating activity and lethality of dl -methamphetamine. Inhibition of the conditioned avoidance response, but not the unconditioned avoidance response, was observed in rats. These effects were observed at levels below the relaxing dose. 4. 4. TNPC exhibited hypothermic action in mice but had no analgesic or sedative action. 5. 5. TNPC had a hypotensive effect in anesthetized cats. This hypotensive effect was not influenced by atropinization, bilateral vagotomy, or removal of bilateral carotid bodies. Also pretreatment with diphenhydramine and dichlorisoproterenol did not influence the hypotensive effect of TNPC. TNPC showed a hypotensive effect in spinal cats, but less strong than that induced in intact animals." @default.
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- W2072214145 date "1967-11-01" @default.
- W2072214145 modified "2023-09-25" @default.
- W2072214145 title "The central depressant profile of carbamate ester of glycerol ether: 3-(1,2,3,4-tetrahydro-7-naphthyloxy)-2-hydroxypropyl carbamate" @default.
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- W2072214145 doi "https://doi.org/10.1016/0041-008x(67)90060-9" @default.
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