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• W2072216099 endingPage "11734" @default.
• W2072216099 startingPage "11729" @default.
• W2072216099 abstract "In many cells, ATP-sensitive K+ channels (KATP channels) couple metabolic state to excitability. In pancreatic beta cells, for example, this coupling regulates insulin release. Although KATP channels are abundantly expressed in the brain, their physiological role and the factors that regulate them are poorly understood. One potential regulator is H2O2. We reported previously that dopamine (DA) release in the striatum is modulated by endogenous H2O2, generated downstream from glutamatergic alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-receptor activation. Here we investigated whether H2O2-sensitive KATP channels contribute to DA-release modulation by glutamate and gamma-aminobutyric acid (GABA). This question is important because DA-glutamate interactions underlie brain functions, including motor control and cognition. Synaptic DA release was evoked by using local electrical stimulation in slices of guinea pig striatum and monitored in real time with carbon-fiber microelectrodes and fast-scan cyclic voltammetry. The KATP-channel antagonist glibenclamide abolished the H2O2-dependent increase in DA release usually seen with AMPA-receptor blockade by GYKI-52466 [1-(4-aminophenyl)-4-methyl-7,8-methylenedioxy-5H-2,3-benzodiazepine hydrochloride] and the decrease in DA release seen with GABA-type-A-receptor blockade by picrotoxin. In contrast, 5-hydroxydecanoate, a mitochondrial KATP-channel blocker, was ineffective, as were sulpiride, a D2-receptor antagonist, and tertiapin, a G protein-coupled K+-channel inhibitor. Diazoxide, a sulfonylurea receptor 1 (SUR1)selective KATP-channel opener, prevented DA modulation by H2O2, glutamate, and GABA, whereas cromakalim, a SUR2-selective opener, did not. Thus, endogenous H2O2 activates SUR1-containing KATP channels in the plasma membrane to inhibit DA release. These data not only demonstrate that KATP channels can modulate CNS transmitter release in response to fast-synaptic transmission but also introduce H2O2 as a KATP-channel regulator." @default.
• W2072216099 created "2016-06-24" @default.
• W2072216099 creator A5043025373 @default.
• W2072216099 creator A5076362309 @default.
• W2072216099 date "2003-09-17" @default.
• W2072216099 modified "2023-09-30" @default.
• W2072216099 title "Activation of ATP-sensitive K ⁺ (K _ATP ) channels by H ₂ O ₂ underlies glutamate-dependent inhibition of striatal dopamine release" @default.
• W2072216099 cites W104554780 @default.
• W2072216099 cites W1487837909 @default.
• W2072216099 cites W1492560211 @default.
• W2072216099 cites W1602287752 @default.
• W2072216099 cites W1664364888 @default.
• W2072216099 cites W179758319 @default.
• W2072216099 cites W1803352854 @default.
• W2072216099 cites W1854633548 @default.
• W2072216099 cites W1863384211 @default.
• W2072216099 cites W1901778362 @default.
• W2072216099 cites W1908602248 @default.
• W2072216099 cites W1925799544 @default.
• W2072216099 cites W1958062876 @default.
• W2072216099 cites W1965102543 @default.
• W2072216099 cites W1971406405 @default.
• W2072216099 cites W1977113086 @default.
• W2072216099 cites W1980826539 @default.
• W2072216099 cites W1981726541 @default.
• W2072216099 cites W1982324844 @default.
• W2072216099 cites W1982817785 @default.
• W2072216099 cites W1983011541 @default.
• W2072216099 cites W1984861949 @default.
• W2072216099 cites W1985770721 @default.
• W2072216099 cites W1986804446 @default.
• W2072216099 cites W1987695766 @default.
• W2072216099 cites W1989397993 @default.
• W2072216099 cites W1990230771 @default.
• W2072216099 cites W2002698668 @default.
• W2072216099 cites W2002965269 @default.
• W2072216099 cites W2003976073 @default.
• W2072216099 cites W2009351843 @default.
• W2072216099 cites W2011275122 @default.
• W2072216099 cites W2014479855 @default.
• W2072216099 cites W2014580405 @default.
• W2072216099 cites W2018150368 @default.
• W2072216099 cites W2019363012 @default.
• W2072216099 cites W2021782736 @default.
• W2072216099 cites W2022233762 @default.
• W2072216099 cites W2023626419 @default.
• W2072216099 cites W2025333162 @default.
• W2072216099 cites W2025821901 @default.
• W2072216099 cites W2026339353 @default.
• W2072216099 cites W2031997571 @default.
• W2072216099 cites W2032301927 @default.
• W2072216099 cites W2032551046 @default.
• W2072216099 cites W2035596916 @default.
• W2072216099 cites W2043899013 @default.
• W2072216099 cites W2046736982 @default.
• W2072216099 cites W2050342883 @default.
• W2072216099 cites W2050369334 @default.
• W2072216099 cites W2053926985 @default.
• W2072216099 cites W2055189403 @default.
• W2072216099 cites W2059349873 @default.
• W2072216099 cites W2060964837 @default.
• W2072216099 cites W2062418245 @default.
• W2072216099 cites W2064688638 @default.
• W2072216099 cites W2064953660 @default.
• W2072216099 cites W2066650398 @default.
• W2072216099 cites W2069214845 @default.
• W2072216099 cites W2076529071 @default.
• W2072216099 cites W2078877182 @default.
• W2072216099 cites W2082333803 @default.
• W2072216099 cites W2082403125 @default.
• W2072216099 cites W2083584165 @default.
• W2072216099 cites W2084037867 @default.
• W2072216099 cites W2084391606 @default.
• W2072216099 cites W2084716996 @default.
• W2072216099 cites W2089705708 @default.
• W2072216099 cites W2092303362 @default.
• W2072216099 cites W2094858856 @default.
• W2072216099 cites W2099067119 @default.
• W2072216099 cites W2109938472 @default.
• W2072216099 cites W2117124733 @default.
• W2072216099 cites W2118937182 @default.
• W2072216099 cites W2121947657 @default.
• W2072216099 cites W2126877541 @default.
• W2072216099 cites W2137771855 @default.
• W2072216099 cites W2143959688 @default.
• W2072216099 cites W2145824374 @default.
• W2072216099 cites W2157658985 @default.
• W2072216099 cites W2157984060 @default.
• W2072216099 cites W2162324718 @default.
• W2072216099 cites W2162947167 @default.
• W2072216099 cites W2166610424 @default.
• W2072216099 cites W2211767371 @default.
• W2072216099 cites W2240478232 @default.
• W2072216099 cites W2287333882 @default.
• W2072216099 cites W2322029934 @default.
• W2072216099 cites W2416678766 @default.
• W2072216099 cites W2439084192 @default.
• W2072216099 doi "https://doi.org/10.1073/pnas.1834314100" @default.

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