FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2072227203> ?p ?o ?g. }

• W2072227203 endingPage "H13" @default.
• W2072227203 startingPage "H9" @default.
• W2072227203 abstract "Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with multiorgan involvement characterized by an immune response against nuclear components. SLE patients experience a waxing and waning disease course and exhibit a wide array of clinical manifestations, reflecting the systemic nature of the disease. Environmental triggers such as viruses are likely to act in the context of susceptibility genes, including genes involved in antigen/immune complex clearance, lymphoid signalling, or apoptosis, among several others, explaining why the pathogenesis of this disease remains largely uncovered. The abnormal activation of the innate immunity is central to SLE physiopathology. Dendritic cells activation and unabated secretion of IFN-alpha are the key features of the disease through their involvement in the capture and the presentation of nuclear material to the autoreactive adaptive arm (T and B lymphocytes) leading to the subsequent production of anti-nuclear autoantibodies. In this line, numerous studies have demonstrated the prominent role of immune complexes deposition throughout the body which directly can induce inflammation and tissue damage. However, animal models and recent human studies support the concept that other effector pathways including cytotoxic T-lymphocytes could be involved in SLE pathogenesis through their ability to migrate and/or target specifically different tissues. The aim of this review is not to provide a comprehensive review of the SLE pathophysiology but rather to give an overview of the immunological abnormalities associated to SLE. The treatments that are currently used or that are in development to fight against abnormal immune response in SLE will be detailed. The genetics of SLE is not the scope of this review." @default.
• W2072227203 created "2016-06-24" @default.
• W2072227203 creator A5012313374 @default.
• W2072227203 creator A5018396975 @default.
• W2072227203 creator A5051152771 @default.
• W2072227203 creator A5056713408 @default.
• W2072227203 creator A5075236193 @default.
• W2072227203 creator A5075692951 @default.
• W2072227203 date "2009-12-01" @default.
• W2072227203 modified "2023-09-30" @default.
• W2072227203 title "Lupus érythémateux systémique : de la physiopathologie au traitement" @default.
• W2072227203 cites W1555063324 @default.
• W2072227203 cites W1625166229 @default.
• W2072227203 cites W1818618334 @default.
• W2072227203 cites W1824998980 @default.
• W2072227203 cites W1998848716 @default.
• W2072227203 cites W2009067699 @default.
• W2072227203 cites W2023684680 @default.
• W2072227203 cites W2028987576 @default.
• W2072227203 cites W2029980677 @default.
• W2072227203 cites W2031317458 @default.
• W2072227203 cites W2035809290 @default.
• W2072227203 cites W2058581379 @default.
• W2072227203 cites W2065907531 @default.
• W2072227203 cites W2078009629 @default.
• W2072227203 cites W2087092773 @default.
• W2072227203 cites W2095287464 @default.
• W2072227203 cites W2106273198 @default.
• W2072227203 cites W2124861138 @default.
• W2072227203 cites W2125054474 @default.
• W2072227203 cites W2131727319 @default.
• W2072227203 cites W2135110049 @default.
• W2072227203 cites W2142043065 @default.
• W2072227203 cites W2146872006 @default.
• W2072227203 cites W2150932450 @default.
• W2072227203 cites W2156138099 @default.
• W2072227203 cites W2159287844 @default.
• W2072227203 cites W2168888135 @default.
• W2072227203 cites W2414784657 @default.
• W2072227203 doi "https://doi.org/10.1016/s0248-8663(09)73167-4" @default.
• W2072227203 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19995652" @default.
• W2072227203 hasPublicationYear "2009" @default.
• W2072227203 type Work @default.
• W2072227203 sameAs 2072227203 @default.
• W2072227203 citedByCount "5" @default.
• W2072227203 countsByYear W20722272032015 @default.
• W2072227203 countsByYear W20722272032016 @default.
• W2072227203 countsByYear W20722272032018 @default.
• W2072227203 countsByYear W20722272032021 @default.
• W2072227203 countsByYear W20722272032022 @default.
• W2072227203 crossrefType "journal-article" @default.
• W2072227203 hasAuthorship W2072227203A5012313374 @default.
• W2072227203 hasAuthorship W2072227203A5018396975 @default.
• W2072227203 hasAuthorship W2072227203A5051152771 @default.
• W2072227203 hasAuthorship W2072227203A5056713408 @default.
• W2072227203 hasAuthorship W2072227203A5075236193 @default.
• W2072227203 hasAuthorship W2072227203A5075692951 @default.
• W2072227203 hasConcept C142724271 @default.
• W2072227203 hasConcept C151730666 @default.
• W2072227203 hasConcept C154317977 @default.
• W2072227203 hasConcept C159654299 @default.
• W2072227203 hasConcept C163764329 @default.
• W2072227203 hasConcept C193419808 @default.
• W2072227203 hasConcept C202751555 @default.
• W2072227203 hasConcept C203014093 @default.
• W2072227203 hasConcept C2776912625 @default.
• W2072227203 hasConcept C2776914184 @default.
• W2072227203 hasConcept C2779075594 @default.
• W2072227203 hasConcept C2779134260 @default.
• W2072227203 hasConcept C2779343474 @default.
• W2072227203 hasConcept C2780130043 @default.
• W2072227203 hasConcept C2780942790 @default.
• W2072227203 hasConcept C54355233 @default.
• W2072227203 hasConcept C71924100 @default.
• W2072227203 hasConcept C86803240 @default.
• W2072227203 hasConcept C8891405 @default.
• W2072227203 hasConceptScore W2072227203C142724271 @default.
• W2072227203 hasConceptScore W2072227203C151730666 @default.
• W2072227203 hasConceptScore W2072227203C154317977 @default.
• W2072227203 hasConceptScore W2072227203C159654299 @default.
• W2072227203 hasConceptScore W2072227203C163764329 @default.
• W2072227203 hasConceptScore W2072227203C193419808 @default.
• W2072227203 hasConceptScore W2072227203C202751555 @default.
• W2072227203 hasConceptScore W2072227203C203014093 @default.
• W2072227203 hasConceptScore W2072227203C2776912625 @default.
• W2072227203 hasConceptScore W2072227203C2776914184 @default.
• W2072227203 hasConceptScore W2072227203C2779075594 @default.
• W2072227203 hasConceptScore W2072227203C2779134260 @default.
• W2072227203 hasConceptScore W2072227203C2779343474 @default.
• W2072227203 hasConceptScore W2072227203C2780130043 @default.
• W2072227203 hasConceptScore W2072227203C2780942790 @default.
• W2072227203 hasConceptScore W2072227203C54355233 @default.
• W2072227203 hasConceptScore W2072227203C71924100 @default.
• W2072227203 hasConceptScore W2072227203C86803240 @default.
• W2072227203 hasConceptScore W2072227203C8891405 @default.
• W2072227203 hasIssue "12" @default.
• W2072227203 hasLocation W20722272031 @default.
• W2072227203 hasLocation W20722272032 @default.

• next