FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2072229430> ?p ?o ?g. }

• W2072229430 endingPage "109" @default.
• W2072229430 startingPage "101" @default.
• W2072229430 abstract "We recently demonstrated that the occupancy of endothelial protein C receptor (EPCR) by its natural ligand activated protein C (APC)/protein C switches the protease activated receptor 1 (PAR-1)-dependent signaling specificity of thrombin from a disruptive to a protective effect in cultured human umbilical vein endothelial cells. Given the phenotypic differences between endothelial cells in venular and arterial beds, in this study we evaluated the signaling function of thrombin in human pulmonary artery endothelial cells (HPAECs) before and after treating them with PC-S195A which lacks catalytic activity but exhibits a normal affinity for EPCR. As expected, both thrombin and thrombin receptor agonist peptide (TRAP) enhanced the permeability barrier of HPAECs; however, both PAR-1 agonists exhibited a potent barrier protective effect when the cells were treated with PC-S195A prior to stimulation by the agonists. Interestingly, similar to APC, thrombin exhibited a potent cytoprotective activity in the LPS-induced permeability and TNF-alpha-induced apoptosis and adhesion assays in the PC-S195A treated HPAECs. Treatment of HPAECs with the cholesterol depleting molecule methyl-beta-cyclodextrin eliminated the protective effect of both APC and thrombin. These results suggest that the occupancy of EPCR by its natural ligand recruits PAR-1 to a protective signaling pathway within lipid rafts of HPAECs. Based on these results we conclude that the activation of PAR-1 by thrombin would initiate a protective response in intact arterial vascular cells expressing EPCR. These findings may have important ramifications for understanding the mechanism of the participation of the vascular PAR-1 in pathophysiology of the inflammatory disorders." @default.
• W2072229430 created "2016-06-24" @default.
• W2072229430 creator A5019234325 @default.
• W2072229430 creator A5054602576 @default.
• W2072229430 date "2008-01-01" @default.
• W2072229430 modified "2023-10-10" @default.
• W2072229430 title "Protease activated receptor 1 (PAR-1) activation by thrombin is protective in human pulmonary artery endothelial cells if endothelial protein C receptor is occupied by its natural ligand" @default.
• W2072229430 cites W132642117 @default.
• W2072229430 cites W1518197977 @default.
• W2072229430 cites W167480335 @default.
• W2072229430 cites W1768301393 @default.
• W2072229430 cites W19495342 @default.
• W2072229430 cites W1956481325 @default.
• W2072229430 cites W1966546527 @default.
• W2072229430 cites W1977766283 @default.
• W2072229430 cites W1990880819 @default.
• W2072229430 cites W2000985786 @default.
• W2072229430 cites W2003239886 @default.
• W2072229430 cites W2004554331 @default.
• W2072229430 cites W2008545520 @default.
• W2072229430 cites W2016576898 @default.
• W2072229430 cites W2020363094 @default.
• W2072229430 cites W2020550595 @default.
• W2072229430 cites W2020863075 @default.
• W2072229430 cites W2026106674 @default.
• W2072229430 cites W2038613048 @default.
• W2072229430 cites W2040968233 @default.
• W2072229430 cites W2050569979 @default.
• W2072229430 cites W2058252463 @default.
• W2072229430 cites W2062984106 @default.
• W2072229430 cites W2063704060 @default.
• W2072229430 cites W2063908549 @default.
• W2072229430 cites W2064296383 @default.
• W2072229430 cites W2073806998 @default.
• W2072229430 cites W2080846452 @default.
• W2072229430 cites W2119370360 @default.
• W2072229430 cites W2120555366 @default.
• W2072229430 cites W2125756319 @default.
• W2072229430 cites W2148127512 @default.
• W2072229430 cites W2148511071 @default.
• W2072229430 cites W2156036748 @default.
• W2072229430 cites W2261467449 @default.
• W2072229430 cites W2322121630 @default.
• W2072229430 doi "https://doi.org/10.1160/th08-02-0127" @default.
• W2072229430 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2562749" @default.
• W2072229430 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18612544" @default.
• W2072229430 hasPublicationYear "2008" @default.
• W2072229430 type Work @default.
• W2072229430 sameAs 2072229430 @default.
• W2072229430 citedByCount "121" @default.
• W2072229430 countsByYear W20722294302012 @default.
• W2072229430 countsByYear W20722294302013 @default.
• W2072229430 countsByYear W20722294302014 @default.
• W2072229430 countsByYear W20722294302015 @default.
• W2072229430 countsByYear W20722294302016 @default.
• W2072229430 countsByYear W20722294302017 @default.
• W2072229430 countsByYear W20722294302018 @default.
• W2072229430 countsByYear W20722294302019 @default.
• W2072229430 countsByYear W20722294302020 @default.
• W2072229430 countsByYear W20722294302021 @default.
• W2072229430 countsByYear W20722294302022 @default.
• W2072229430 countsByYear W20722294302023 @default.
• W2072229430 crossrefType "journal-article" @default.
• W2072229430 hasAuthorship W2072229430A5019234325 @default.
• W2072229430 hasAuthorship W2072229430A5054602576 @default.
• W2072229430 hasBestOaLocation W20722294302 @default.
• W2072229430 hasConcept C134018914 @default.
• W2072229430 hasConcept C149577978 @default.
• W2072229430 hasConcept C170493617 @default.
• W2072229430 hasConcept C185592680 @default.
• W2072229430 hasConcept C201267052 @default.
• W2072229430 hasConcept C203014093 @default.
• W2072229430 hasConcept C2776816377 @default.
• W2072229430 hasConcept C2776992346 @default.
• W2072229430 hasConcept C2777292125 @default.
• W2072229430 hasConcept C2781287897 @default.
• W2072229430 hasConcept C55493867 @default.
• W2072229430 hasConcept C86803240 @default.
• W2072229430 hasConcept C89560881 @default.
• W2072229430 hasConcept C95444343 @default.
• W2072229430 hasConcept C98274493 @default.
• W2072229430 hasConceptScore W2072229430C134018914 @default.
• W2072229430 hasConceptScore W2072229430C149577978 @default.
• W2072229430 hasConceptScore W2072229430C170493617 @default.
• W2072229430 hasConceptScore W2072229430C185592680 @default.
• W2072229430 hasConceptScore W2072229430C201267052 @default.
• W2072229430 hasConceptScore W2072229430C203014093 @default.
• W2072229430 hasConceptScore W2072229430C2776816377 @default.
• W2072229430 hasConceptScore W2072229430C2776992346 @default.
• W2072229430 hasConceptScore W2072229430C2777292125 @default.
• W2072229430 hasConceptScore W2072229430C2781287897 @default.
• W2072229430 hasConceptScore W2072229430C55493867 @default.
• W2072229430 hasConceptScore W2072229430C86803240 @default.
• W2072229430 hasConceptScore W2072229430C89560881 @default.
• W2072229430 hasConceptScore W2072229430C95444343 @default.
• W2072229430 hasConceptScore W2072229430C98274493 @default.
• W2072229430 hasIssue "07" @default.
• W2072229430 hasLocation W20722294301 @default.

• next