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• W2072233757 abstract "ISEE-316 Introduction: The objective of this study was to assess epidemiological variables and evaluate cholinesterase levels as well as other biological exposure indicators among pesticide workers exposed to organophosphates at Vale do São Lourenço, an area producing vegetables for Rio de Janeiro's consumption market in Brazil. Methods: Plasma and erythrocyte acetylcholinesterase activities were measured using Ellman′s method in a group of 101 exposed workers and 185 non-exposed people identified as a control group. Urinary p-nitrophenol levels were analysed by an HPLC method developed and validated in our laboratory. Urine and blood samples were obtained at the same time, in the morning after one usual spraying shift. Clinical evaluations were performed to assess important signs and symptoms of intoxication related to organophosphates exposure. A questionnaire was also administered to assess important occupational exposure variables and to investigate possible associations between biological monitoring, epidemiological and clinical data. Results: We have tested cut-off points to dichotomize cholinesterase levels into low and normal categories, based on the 5th, 10th and 25th percentile from the normal distribution of controls. In relation to erythrocyte acetylcholinesterase, our results showed significant associations in the low category group, as compared to the normal category group in the following situations: (i) activity of applying or mixing pesticides (OR=3.12 - 95 %CI =0.97–10); (ii) more than 3 hours work shift spraying pesticides OR=2.43 (0.99–6); (iii) the last used pesticide was an organophophate OR=3.39 (1.34–8.53); (iv) reported insomnia OR=2.47 (0.98–6.22) and (v) signs of muscle fasciculation or=2.48(1.01–6.06). Also, we have developed an HPLC method to analyse p-nitrophenol and its urinary conjugates. These metabolites are end products of parathion and methyl parathion metabolism, and can be used as internal dose biomarkers in cases of exposure to these organophosphate pesticides. Results from 7 urine samples from workers exposed to parathion and methyl parathion showed that p-nitrophenol levels were not clearly associated with lower levels of cholinesterases. Conclusion: Evaluation of organophosphate pesticide overexposure and/or intoxication has to be determined with as many sensitive indicators as possible, to assess an actual profile of health status of individuals under exposure. Cholinesterases alone are not sensitive predictors of sub-acute exposure and analysis of this biological indicator has limitations that would be minimized by using several others parameters assessed in toxicological and epidemiological analyses." @default.
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• W2072233757 date "2005-09-01" @default.
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• W2072233757 title "BIOLOGICAL MONITORING AND CLINICAL EVALUATION OF PESTICIDES APPLICATORS EXPOSED TO ORGANOPHOSPHATES IN AN AGRICULTURAL AREA AT RIO DE JANEIRO STATE, BRAZIL" @default.
• W2072233757 doi "https://doi.org/10.1097/00001648-200509000-00305" @default.
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