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• W2072235145 abstract "<i>Background:</i> Portal flow diversion by portacaval shunts (PCS) has been shown to prevent primary graft nonfunction in liver transplantation using small-for-size grafts. In this study, we examine whether PCS can improve reperfusion injury after major hepatectomy in pigs. <i>Materials and Methods:</i> In 14 pigs, a partial PCS was constructed following 65% hepatectomy and 1 h of inflow ischemia. During 24 h of reperfusion, the shunt was either closed (group A, n = 7) or left open (group B, n = 7). <i>Results:</i> 24 h after reperfusion, group A had higher levels of alanine aminotransferase (70 ± 12 IU/l vs. 51 ± 5.9 IU/l; p < 0.05), alanine aminotransferase per gram of liver remnant (0.41 ± 0.07 IU/l/g vs. 0.21 ± 0.05 IU/l/g; p < 0.05), prothrombin time (24.1 ± 2.4 s vs. 14.3 ± 2.9 s; p < 0.05), international normalized ratio (2.11 ± 0.15 vs. 1.29 ± 0.28; p < 0.05), hepatocyte necrosis scores and percentages of nuclei stained for proliferating cell nuclear antigen (52.57 ± 8.9% vs. 36.71 ± 6%; p < 0.05) compared to group B. <i>Conclusions:</i> Partial portal flow diversion appears to attenuate reperfusion injury in a porcine model of major hepatectomy." @default.
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• W2072235145 date "2008-01-01" @default.
• W2072235145 modified "2023-10-17" @default.
• W2072235145 title "Effect of the Portacaval Shunt on Reperfusion Injury after 65% Hepatectomy in Pigs" @default.
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• W2072235145 doi "https://doi.org/10.1159/000118031" @default.
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