FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2072238097> ?p ?o ?g. }

• W2072238097 endingPage "1094" @default.
• W2072238097 startingPage "1075" @default.
• W2072238097 abstract "p53 is a potent tumor suppressor with a crucial role in preventing uncontrolled cell proliferation and is therefore frequently deleted or mutated in cancer. For tumors with wild-type p53, its function can be overcome by overactive cellular antagonists, such as the ubiquitin ligase murine double minute clone 2 (MDM2). Restoring p53 activity by inhibiting MDM2 in such cancers can eradicate tumors. Consequently, the MDM2–p53 interaction has been extensively targeted for inhibition by small molecules. In recent years, MDM2-like protein (MDMX), another key downregulator of p53, has gained increasing importance as an additional target for drug development, in order to provide a complementary approach to MDM2 inhibition. In this review, we describe how detailed structural knowledge of the MDM2–p53 interface and, more recently, of the MDMX–p53 interaction have helped advance the development of inhibitors against the two targets. We present a summary of the functional biochemistry of MDM2, MDMX and p53 as well as their interactions and examine recent progress in the development of inhibitors of MDM2 and MDMX." @default.
• W2072238097 created "2016-06-24" @default.
• W2072238097 creator A5029246908 @default.
• W2072238097 creator A5069391427 @default.
• W2072238097 date "2009-09-01" @default.
• W2072238097 modified "2023-10-18" @default.
• W2072238097 title "Inhibitors of MDM2 and MDMX: a structural perspective" @default.
• W2072238097 cites W1560780012 @default.
• W2072238097 cites W1576330810 @default.
• W2072238097 cites W1591281137 @default.
• W2072238097 cites W1639110856 @default.
• W2072238097 cites W1640635403 @default.
• W2072238097 cites W1650797637 @default.
• W2072238097 cites W1822460389 @default.
• W2072238097 cites W1861504067 @default.
• W2072238097 cites W1965173366 @default.
• W2072238097 cites W1965451896 @default.
• W2072238097 cites W1969044026 @default.
• W2072238097 cites W1973399156 @default.
• W2072238097 cites W1975697981 @default.
• W2072238097 cites W1976261939 @default.
• W2072238097 cites W1981190141 @default.
• W2072238097 cites W1982259691 @default.
• W2072238097 cites W1983751803 @default.
• W2072238097 cites W1988112194 @default.
• W2072238097 cites W1991346790 @default.
• W2072238097 cites W1991494214 @default.
• W2072238097 cites W1992190005 @default.
• W2072238097 cites W1992760686 @default.
• W2072238097 cites W1992947288 @default.
• W2072238097 cites W1993170641 @default.
• W2072238097 cites W1993263392 @default.
• W2072238097 cites W1993864973 @default.
• W2072238097 cites W1995095999 @default.
• W2072238097 cites W1995856480 @default.
• W2072238097 cites W1996899753 @default.
• W2072238097 cites W1998735636 @default.
• W2072238097 cites W1998767804 @default.
• W2072238097 cites W2001709898 @default.
• W2072238097 cites W2004273407 @default.
• W2072238097 cites W2004311983 @default.
• W2072238097 cites W2007249806 @default.
• W2072238097 cites W2007658328 @default.
• W2072238097 cites W2012053348 @default.
• W2072238097 cites W2013773309 @default.
• W2072238097 cites W2014749419 @default.
• W2072238097 cites W2018119086 @default.
• W2072238097 cites W2018385269 @default.
• W2072238097 cites W2021516295 @default.
• W2072238097 cites W2022416218 @default.
• W2072238097 cites W2022901265 @default.
• W2072238097 cites W2023950025 @default.
• W2072238097 cites W2024604828 @default.
• W2072238097 cites W2025476423 @default.
• W2072238097 cites W2025963365 @default.
• W2072238097 cites W2027216514 @default.
• W2072238097 cites W2027760571 @default.
• W2072238097 cites W2030214692 @default.
• W2072238097 cites W2030283142 @default.
• W2072238097 cites W2030650820 @default.
• W2072238097 cites W2034177818 @default.
• W2072238097 cites W2035177083 @default.
• W2072238097 cites W2036454087 @default.
• W2072238097 cites W2039928024 @default.
• W2072238097 cites W2040159113 @default.
• W2072238097 cites W2043182996 @default.
• W2072238097 cites W2043712638 @default.
• W2072238097 cites W2043730018 @default.
• W2072238097 cites W2044333879 @default.
• W2072238097 cites W2046135777 @default.
• W2072238097 cites W2047132220 @default.
• W2072238097 cites W2047936759 @default.
• W2072238097 cites W2049133549 @default.
• W2072238097 cites W2049527615 @default.
• W2072238097 cites W2050214049 @default.
• W2072238097 cites W2052516738 @default.
• W2072238097 cites W2054074966 @default.
• W2072238097 cites W2054085388 @default.
• W2072238097 cites W2055458365 @default.
• W2072238097 cites W2056169996 @default.
• W2072238097 cites W2058933525 @default.
• W2072238097 cites W2059185804 @default.
• W2072238097 cites W2062552623 @default.
• W2072238097 cites W2062612693 @default.
• W2072238097 cites W2063669247 @default.
• W2072238097 cites W2064264445 @default.
• W2072238097 cites W2064795157 @default.
• W2072238097 cites W2067240980 @default.
• W2072238097 cites W2067368732 @default.
• W2072238097 cites W2069144710 @default.
• W2072238097 cites W2069441772 @default.
• W2072238097 cites W2070932122 @default.
• W2072238097 cites W2072319696 @default.
• W2072238097 cites W2073576377 @default.
• W2072238097 cites W2079828864 @default.
• W2072238097 cites W2081184407 @default.
• W2072238097 cites W2081792763 @default.
• W2072238097 cites W2082979850 @default.

• next