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- W2072244561 abstract "Background. Dedifferentiated chordoma is an unusual and aggressive variant of chordoma which is likely to metastasize. Few reports exist of treatment of these tumors with chemotherapy. Methods. In 1988, two patients with dedifferentiated sacral chordomas were seen at the University of Chicago Hospitals. Both developed metastatic disease less than a year after sacral resection and radiation therapy. These patients' diagnoses, courses, and treatments were reviewed along with the literature on chemotherapy in both conventional and dedifferentiated chordomas. Results. Both patients obtained complete remissions, one to a six-drug regimen and the other to ifosfamide. Conclusions. A trial of reasonably aggressive chemotherapy is warranted in patients with metastatic dedifferentiated chordoma. The optimum regimen is unclear, but agents active in high-grade sarcomas are logical choices." @default.
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- W2072244561 date "1993-08-01" @default.
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- W2072244561 title "Dedifferentiated chordoma: Response to aggressive chemotherapy in two cases" @default.
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- W2072244561 doi "https://doi.org/10.1002/1097-0142(19930801)72:3<714::aid-cncr2820720314>3.0.co;2-1" @default.
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