FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2072246662> ?p ?o ?g. }

• W2072246662 endingPage "1933" @default.
• W2072246662 startingPage "1918" @default.
• W2072246662 abstract "Whereas 25 to 50% of selected patients with gynecologic tumors who relapse centrally in an irradiated pelvis can be salvaged by exenteration, postirradiation recurrence infiltrating the pelvic side wall generally has been fatal. We have designed the combined operative and radiotherapeutic treatment (CORT) procedure for the treatment of postirradiation recurrence infiltrating the pelvic wall and developed several new techniques for its realization. The aim of the surgery is as follows: (1) total resection of the tumor with only a microscopic margin (R1) at the pelvic wall, preserving the bony pelvis and the neurovascular support of the leg; (2) modulation of the therapeutic index for a second high-dose irradiation of the pelvic wall by transferring autologous tissue from the abdomen or the thigh, and (3) reconstruction of pelvic organ functions lost due to tumor resection. The tumor bed is irradiated postoperatively with brachytherapy through transcutaneous guide tubes implanted at the pelvic wall.Between April 1989 and December 1994, we treated 48 patients with postirradiation recurrent or persistent gynecologic malignancies infiltrating the pelvic wall with CORT and followed them prospectively with the following endpoints: tumor control, survival, complications, and quality of life.At a median follow-up of 33 months (range, 3-71 months), the 5-year survival probability calculated with the Kaplan-Meier method was 44%. The overall local control rate was 68%, and 85% in the last 25 patients in the series. The censored severe complication rate at 5 years was 33%. No patient died as a consequence of the treatment. Quality of life was self-assessed with a validated questionnaire by 15 patients without evidence of disease, and was rated with a total of 74% of the maximum score points. Age of the patient, state of resection at the pelvic wall (R1 vs. R2), and recurrent tumor size independently influenced tumor progression after CORT in this series.CORT appears to be a feasible, innovative treatment with long term survival potential and acceptable quality of life for selected patients with postirradiation gynecologic tumor recurrence infiltrating the pelvic wall. R1 resection of the tumor at the pelvic wall is mandatory; however, the reconstruction options within the pelvis are limited." @default.
• W2072246662 created "2016-06-24" @default.
• W2072246662 creator A5038463012 @default.
• W2072246662 creator A5042738636 @default.
• W2072246662 creator A5049970040 @default.
• W2072246662 creator A5055087216 @default.
• W2072246662 creator A5064509047 @default.
• W2072246662 creator A5071429446 @default.
• W2072246662 date "1996-05-01" @default.
• W2072246662 modified "2023-10-18" @default.
• W2072246662 title "Five-year experience with combined operative and radiotherapeutic treatment of recurrent gynecologic tumors infiltrating the pelvic wall" @default.
• W2072246662 cites W1554115039 @default.
• W2072246662 cites W1596138315 @default.
• W2072246662 cites W1643461708 @default.
• W2072246662 cites W1695841965 @default.
• W2072246662 cites W1706690357 @default.
• W2072246662 cites W1857380442 @default.
• W2072246662 cites W1967798221 @default.
• W2072246662 cites W1976239038 @default.
• W2072246662 cites W1979364975 @default.
• W2072246662 cites W1982433294 @default.
• W2072246662 cites W1982702719 @default.
• W2072246662 cites W1986203782 @default.
• W2072246662 cites W1988767707 @default.
• W2072246662 cites W1989379878 @default.
• W2072246662 cites W1995170578 @default.
• W2072246662 cites W1996954675 @default.
• W2072246662 cites W2003602264 @default.
• W2072246662 cites W2009689615 @default.
• W2072246662 cites W2010946889 @default.
• W2072246662 cites W2012124058 @default.
• W2072246662 cites W2013436421 @default.
• W2072246662 cites W2016745497 @default.
• W2072246662 cites W2018948957 @default.
• W2072246662 cites W2033450259 @default.
• W2072246662 cites W2036059671 @default.
• W2072246662 cites W2038514570 @default.
• W2072246662 cites W2041953782 @default.
• W2072246662 cites W2049183709 @default.
• W2072246662 cites W2053244230 @default.
• W2072246662 cites W2059373634 @default.
• W2072246662 cites W2059980943 @default.
• W2072246662 cites W2061981737 @default.
• W2072246662 cites W2078599646 @default.
• W2072246662 cites W2081032227 @default.
• W2072246662 cites W2082292187 @default.
• W2072246662 cites W2083317960 @default.
• W2072246662 cites W2083405173 @default.
• W2072246662 cites W2092267949 @default.
• W2072246662 cites W2105258029 @default.
• W2072246662 cites W2124312298 @default.
• W2072246662 cites W2262239519 @default.
• W2072246662 cites W2400085368 @default.
• W2072246662 cites W2402020258 @default.
• W2072246662 cites W2410363813 @default.
• W2072246662 cites W2461254977 @default.
• W2072246662 cites W4238350407 @default.
• W2072246662 cites W4242838995 @default.
• W2072246662 cites W4255494875 @default.
• W2072246662 doi "https://doi.org/10.1002/(sici)1097-0142(19960501)77:9<1918::aid-cncr24>3.0.co;2-1" @default.
• W2072246662 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8646694" @default.
• W2072246662 hasPublicationYear "1996" @default.
• W2072246662 type Work @default.
• W2072246662 sameAs 2072246662 @default.
• W2072246662 citedByCount "76" @default.
• W2072246662 countsByYear W20722466622012 @default.
• W2072246662 countsByYear W20722466622014 @default.
• W2072246662 countsByYear W20722466622015 @default.
• W2072246662 countsByYear W20722466622016 @default.
• W2072246662 countsByYear W20722466622017 @default.
• W2072246662 countsByYear W20722466622018 @default.
• W2072246662 countsByYear W20722466622019 @default.
• W2072246662 countsByYear W20722466622020 @default.
• W2072246662 countsByYear W20722466622021 @default.
• W2072246662 countsByYear W20722466622022 @default.
• W2072246662 countsByYear W20722466622023 @default.
• W2072246662 crossrefType "journal-article" @default.
• W2072246662 hasAuthorship W2072246662A5038463012 @default.
• W2072246662 hasAuthorship W2072246662A5042738636 @default.
• W2072246662 hasAuthorship W2072246662A5049970040 @default.
• W2072246662 hasAuthorship W2072246662A5055087216 @default.
• W2072246662 hasAuthorship W2072246662A5064509047 @default.
• W2072246662 hasAuthorship W2072246662A5071429446 @default.
• W2072246662 hasBestOaLocation W20722466621 @default.
• W2072246662 hasConcept C105572291 @default.
• W2072246662 hasConcept C126838900 @default.
• W2072246662 hasConcept C141071460 @default.
• W2072246662 hasConcept C2776140610 @default.
• W2072246662 hasConcept C2777416452 @default.
• W2072246662 hasConcept C2778020340 @default.
• W2072246662 hasConcept C2778357063 @default.
• W2072246662 hasConcept C2779983558 @default.
• W2072246662 hasConcept C509974204 @default.
• W2072246662 hasConcept C71924100 @default.
• W2072246662 hasConcept C81182388 @default.
• W2072246662 hasConceptScore W2072246662C105572291 @default.
• W2072246662 hasConceptScore W2072246662C126838900 @default.
• W2072246662 hasConceptScore W2072246662C141071460 @default.

• next