Matches in SemOpenAlex for { <https://semopenalex.org/work/W2072262673> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2072262673 abstract "4,6-Di-tert-butyl-2,3-dihydro-2,2-dipentyl-5-benzofuranol (BO-653) is a novel antioxidant synthesized by theoretical findings and considerations. Here we report on the aqueous peroxyl radical-induced oxidation of human plasma in the presence of BO-653. When BO-653 was given to healthy human subjects at 400 mg twice daily for 28 days, lipids in the resulting plasma were protected from oxidation compared with lipids present in plasma from subjects receiving placebo. Similarly, BO-653 added in vitro at 50 muM inhibited the peroxyl radical-induced accumulation of cholesteryl ester hydroperoxides that occurred in the presence of alpha-tocopherol, although BO-653 did not decrease the rate of consumption of ascorbate, albumin-bound bilirubin, and uric acid. The antioxidant action of in vivo and in vitro added BO-653 was associated with the formation of two major reaction products of BO-653, the structures of which were elucidated by mass spectrometry and nuclear magnetic resonance analyses. The products were identified as stereoisomers of dioxybis(4,6-di-tert.-butyl-2,3,5,7a-tetrahydro-2,2-dipentylbenzofuran-5-one). These dialkylperoxides of BO-653 might be useful markers to assess the antioxidant function of BO-653 in biological systems in vivo." @default.
- W2072262673 created "2016-06-24" @default.
- W2072262673 creator A5002010316 @default.
- W2072262673 creator A5012873224 @default.
- W2072262673 creator A5015511874 @default.
- W2072262673 creator A5032784109 @default.
- W2072262673 creator A5055382542 @default.
- W2072262673 creator A5070280228 @default.
- W2072262673 creator A5088867306 @default.
- W2072262673 date "2005-01-01" @default.
- W2072262673 modified "2023-09-25" @default.
- W2072262673 title "Characterization of the oxidation products of BO-653 formed during peroxyl radical-mediated oxidation of human plasma" @default.
- W2072262673 cites W124588829 @default.
- W2072262673 cites W125627109 @default.
- W2072262673 cites W1509142633 @default.
- W2072262673 cites W1583940462 @default.
- W2072262673 cites W1694105186 @default.
- W2072262673 cites W1857052429 @default.
- W2072262673 cites W1869682857 @default.
- W2072262673 cites W1993202833 @default.
- W2072262673 cites W1996120477 @default.
- W2072262673 cites W2002337501 @default.
- W2072262673 cites W2005910570 @default.
- W2072262673 cites W2021604043 @default.
- W2072262673 cites W2022185157 @default.
- W2072262673 cites W2044220108 @default.
- W2072262673 cites W2045938742 @default.
- W2072262673 cites W2048039428 @default.
- W2072262673 cites W2052169580 @default.
- W2072262673 cites W2052981361 @default.
- W2072262673 cites W2056735508 @default.
- W2072262673 cites W2067404795 @default.
- W2072262673 cites W2083172467 @default.
- W2072262673 cites W2086819487 @default.
- W2072262673 cites W2089772634 @default.
- W2072262673 cites W2104573407 @default.
- W2072262673 cites W2137368776 @default.
- W2072262673 cites W2139018594 @default.
- W2072262673 cites W2143266144 @default.
- W2072262673 cites W2156075401 @default.
- W2072262673 cites W2163485744 @default.
- W2072262673 cites W2185803857 @default.
- W2072262673 cites W2324034002 @default.
- W2072262673 cites W2330609598 @default.
- W2072262673 doi "https://doi.org/10.1016/j.freeradbiomed.2004.09.018" @default.
- W2072262673 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15589369" @default.
- W2072262673 hasPublicationYear "2005" @default.
- W2072262673 type Work @default.
- W2072262673 sameAs 2072262673 @default.
- W2072262673 citedByCount "2" @default.
- W2072262673 crossrefType "journal-article" @default.
- W2072262673 hasAuthorship W2072262673A5002010316 @default.
- W2072262673 hasAuthorship W2072262673A5012873224 @default.
- W2072262673 hasAuthorship W2072262673A5015511874 @default.
- W2072262673 hasAuthorship W2072262673A5032784109 @default.
- W2072262673 hasAuthorship W2072262673A5055382542 @default.
- W2072262673 hasAuthorship W2072262673A5070280228 @default.
- W2072262673 hasAuthorship W2072262673A5088867306 @default.
- W2072262673 hasConcept C150903083 @default.
- W2072262673 hasConcept C185592680 @default.
- W2072262673 hasConcept C202751555 @default.
- W2072262673 hasConcept C207001950 @default.
- W2072262673 hasConcept C2776778087 @default.
- W2072262673 hasConcept C2778004101 @default.
- W2072262673 hasConcept C2779881121 @default.
- W2072262673 hasConcept C2994476132 @default.
- W2072262673 hasConcept C3020134792 @default.
- W2072262673 hasConcept C43617362 @default.
- W2072262673 hasConcept C55493867 @default.
- W2072262673 hasConcept C86803240 @default.
- W2072262673 hasConceptScore W2072262673C150903083 @default.
- W2072262673 hasConceptScore W2072262673C185592680 @default.
- W2072262673 hasConceptScore W2072262673C202751555 @default.
- W2072262673 hasConceptScore W2072262673C207001950 @default.
- W2072262673 hasConceptScore W2072262673C2776778087 @default.
- W2072262673 hasConceptScore W2072262673C2778004101 @default.
- W2072262673 hasConceptScore W2072262673C2779881121 @default.
- W2072262673 hasConceptScore W2072262673C2994476132 @default.
- W2072262673 hasConceptScore W2072262673C3020134792 @default.
- W2072262673 hasConceptScore W2072262673C43617362 @default.
- W2072262673 hasConceptScore W2072262673C55493867 @default.
- W2072262673 hasConceptScore W2072262673C86803240 @default.
- W2072262673 hasLocation W20722626731 @default.
- W2072262673 hasLocation W20722626732 @default.
- W2072262673 hasOpenAccess W2072262673 @default.
- W2072262673 hasPrimaryLocation W20722626731 @default.
- W2072262673 hasRelatedWork W1988822992 @default.
- W2072262673 hasRelatedWork W2010174101 @default.
- W2072262673 hasRelatedWork W2025372788 @default.
- W2072262673 hasRelatedWork W2057402156 @default.
- W2072262673 hasRelatedWork W2117060331 @default.
- W2072262673 hasRelatedWork W2367582973 @default.
- W2072262673 hasRelatedWork W2409930705 @default.
- W2072262673 hasRelatedWork W2462132595 @default.
- W2072262673 hasRelatedWork W3088505395 @default.
- W2072262673 hasRelatedWork W752283992 @default.
- W2072262673 isParatext "false" @default.
- W2072262673 isRetracted "false" @default.
- W2072262673 magId "2072262673" @default.
- W2072262673 workType "article" @default.