Matches in SemOpenAlex for { <https://semopenalex.org/work/W2072262935> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2072262935 endingPage "343" @default.
- W2072262935 startingPage "337" @default.
- W2072262935 abstract "It is well known that human lymphoblastoid interferon-α [HuIFN-α(ly)] may either increase or decrease antibody production by B cells, in vivo as well as in vitro, depending on the experimental conditions and the system used. We compare here the effect of HuIFN-α(ly) and human recombinant interferon-α (rHuIFN-α) on immunoglobulin M (IgM) production by secreting and nonsecreting human B-like lymphoblastoid cells, respectively, ST8246, and Daudi cells. Under our experimental conditions, Daudi cells were less sensitive to the antiproliferative effect of IFN than previously reported by other authors, and ST8246 cells were insensitive to this antiproliferative effect. In contrast, IgM production was profoundly affected in both cell lines. Thus, we could discriminate between the effect on cell growth from the effect on the immune response. Using high-pressure liquid chromatography (HPLC) separation, μ chains and monomeric and pentameric IgM were distinguished from cytosolic and membrane-associated fractions and from culture medium (extracellular IgM). Pentameric extracellular IgM and monomeric membrane IgM were diminished by HuIFN-α(ly) treatment, respectively, in ST8246 cells and in Daudi cells. We conclude that HuIFN-α(ly) induces regression of B-like lymphoblastoid cells toward a less mature phenotype." @default.
- W2072262935 created "2016-06-24" @default.
- W2072262935 creator A5016049260 @default.
- W2072262935 creator A5019137666 @default.
- W2072262935 creator A5023391546 @default.
- W2072262935 creator A5048505630 @default.
- W2072262935 creator A5076736473 @default.
- W2072262935 creator A5082726314 @default.
- W2072262935 date "1992-10-01" @default.
- W2072262935 modified "2023-09-26" @default.
- W2072262935 title "Human Interferons-α Inhibit the Production of Immunoglobulin M by Secreting and Nonsecreting Lymphoblastoid Cell Lines" @default.
- W2072262935 cites W1497979607 @default.
- W2072262935 cites W1556922550 @default.
- W2072262935 cites W1713797017 @default.
- W2072262935 cites W1963689659 @default.
- W2072262935 cites W1989913523 @default.
- W2072262935 cites W1990866218 @default.
- W2072262935 cites W2010127283 @default.
- W2072262935 cites W2018633923 @default.
- W2072262935 cites W2026413275 @default.
- W2072262935 cites W2038901856 @default.
- W2072262935 cites W2042708086 @default.
- W2072262935 cites W2044658526 @default.
- W2072262935 cites W2046171723 @default.
- W2072262935 cites W2052695693 @default.
- W2072262935 cites W2053495167 @default.
- W2072262935 cites W2054120235 @default.
- W2072262935 cites W2059558137 @default.
- W2072262935 cites W2085062936 @default.
- W2072262935 cites W2087977085 @default.
- W2072262935 cites W2101387721 @default.
- W2072262935 cites W2147598378 @default.
- W2072262935 cites W2157228835 @default.
- W2072262935 cites W2235894312 @default.
- W2072262935 doi "https://doi.org/10.1089/jir.1992.12.337" @default.
- W2072262935 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1431313" @default.
- W2072262935 hasPublicationYear "1992" @default.
- W2072262935 type Work @default.
- W2072262935 sameAs 2072262935 @default.
- W2072262935 citedByCount "1" @default.
- W2072262935 crossrefType "journal-article" @default.
- W2072262935 hasAuthorship W2072262935A5016049260 @default.
- W2072262935 hasAuthorship W2072262935A5019137666 @default.
- W2072262935 hasAuthorship W2072262935A5023391546 @default.
- W2072262935 hasAuthorship W2072262935A5048505630 @default.
- W2072262935 hasAuthorship W2072262935A5076736473 @default.
- W2072262935 hasAuthorship W2072262935A5082726314 @default.
- W2072262935 hasConcept C113842279 @default.
- W2072262935 hasConcept C141105273 @default.
- W2072262935 hasConcept C153911025 @default.
- W2072262935 hasConcept C159654299 @default.
- W2072262935 hasConcept C202751555 @default.
- W2072262935 hasConcept C203014093 @default.
- W2072262935 hasConcept C207001950 @default.
- W2072262935 hasConcept C2776178377 @default.
- W2072262935 hasConcept C28406088 @default.
- W2072262935 hasConcept C54355233 @default.
- W2072262935 hasConcept C55493867 @default.
- W2072262935 hasConcept C81885089 @default.
- W2072262935 hasConcept C86803240 @default.
- W2072262935 hasConcept C8891405 @default.
- W2072262935 hasConceptScore W2072262935C113842279 @default.
- W2072262935 hasConceptScore W2072262935C141105273 @default.
- W2072262935 hasConceptScore W2072262935C153911025 @default.
- W2072262935 hasConceptScore W2072262935C159654299 @default.
- W2072262935 hasConceptScore W2072262935C202751555 @default.
- W2072262935 hasConceptScore W2072262935C203014093 @default.
- W2072262935 hasConceptScore W2072262935C207001950 @default.
- W2072262935 hasConceptScore W2072262935C2776178377 @default.
- W2072262935 hasConceptScore W2072262935C28406088 @default.
- W2072262935 hasConceptScore W2072262935C54355233 @default.
- W2072262935 hasConceptScore W2072262935C55493867 @default.
- W2072262935 hasConceptScore W2072262935C81885089 @default.
- W2072262935 hasConceptScore W2072262935C86803240 @default.
- W2072262935 hasConceptScore W2072262935C8891405 @default.
- W2072262935 hasIssue "5" @default.
- W2072262935 hasLocation W20722629351 @default.
- W2072262935 hasLocation W20722629352 @default.
- W2072262935 hasOpenAccess W2072262935 @default.
- W2072262935 hasPrimaryLocation W20722629351 @default.
- W2072262935 hasRelatedWork W1856085589 @default.
- W2072262935 hasRelatedWork W1988863520 @default.
- W2072262935 hasRelatedWork W1999407296 @default.
- W2072262935 hasRelatedWork W2020692772 @default.
- W2072262935 hasRelatedWork W2054843986 @default.
- W2072262935 hasRelatedWork W2087982072 @default.
- W2072262935 hasRelatedWork W2411508074 @default.
- W2072262935 hasRelatedWork W2464301138 @default.
- W2072262935 hasRelatedWork W4237802932 @default.
- W2072262935 hasRelatedWork W120488427 @default.
- W2072262935 hasVolume "12" @default.
- W2072262935 isParatext "false" @default.
- W2072262935 isRetracted "false" @default.
- W2072262935 magId "2072262935" @default.
- W2072262935 workType "article" @default.