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- W2072264612 abstract "Platelets stored in CLX blood bags, under normal blood banking conditions, were studied for up to 7 days to determine if changes occurred in the levels of membrane glycoproteins (GP) Ib-IX and IIb-IIIa. Radiolabeled monoclonal antibodies (MAB) were used to estimate the number of glycoprotein molecules on the surface membrane of intact platelets. GP IX and GP IIb-IIIa levels remained essentially unaltered during storage. In contrast, the content of GP Ib at day 7 decreased by 45% of the total when fresh. The aggregation response to ristocetin, which requires GP Ib, was also diminished after 7 days. Addition of protease inhibitors, leupeptin and/or aprotinin did not appear to influence the degradation of this glycoprotein. We conclude that storage at 22 degrees C had deleterious effects on the GP Ib content of platelets." @default.
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- W2072264612 date "1992-06-01" @default.
- W2072264612 modified "2023-09-25" @default.
- W2072264612 title "Alterations of the levels of glycoproteins Ib-IX and IIb-IIIa in platelets stored at 22°C" @default.
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- W2072264612 doi "https://doi.org/10.1016/0049-3848(92)90038-c" @default.
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