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- W2072267194 abstract "The Katz track-model of cell inactivation has been more successful than any other biophysical model in fitting and predicting inactivation of mammalian cells exposed to a wide variety of ionising radiations. Although the model was developed as a parameterised phenomenological description, without necessarily implying any particular mechanistic processes, the present analysis attempts to interpret it and thereby benefit further from its success to date. A literal interpretation of the parameters leads to contradictions with other experimental and theoretical information, especially since the fitted parameters imply very large (≥4 μm) subcellular sensitive sites which each require very large amounts (≥100 keV) of energy deposition in order to be inactivated. Comparisons of these fits with those for cell mutation suggest a re-interpretation in terms of (1) very much smaller sites and (2) a clearer distinction between the ion-kill and γ-kill modes of inactivation. It is suggested that this re-interpretation may be able to guide future development of the phenomenological Katz model and also parameterisation of mechanistic biophysical models." @default.
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- W2072267194 date "1989-01-01" @default.
- W2072267194 modified "2023-09-26" @default.
- W2072267194 title "Relationships of radiation track structure to biological effect: A re-interpretation of the parameters of the Katz model" @default.
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- W2072267194 doi "https://doi.org/10.1016/1359-0189(89)90048-4" @default.
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