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- W2072269780 abstract "Developmental changes in the sensitivity of neurons to tetrodotoxin (TTX) were studied in relation to the cell size in rat dorsal root ganglia (DRG). Na+ currents were recorded from neurons of various stages of development. Two types of Na+ channels were identified on the basis of their sensitivity to TTX. One type was insensitive to a very high concentration (0.1 mM) of TTX, while the other type was blocked by a low concentration (1 nM) of TTX. These two types of Na+ channels were observed throughout the developmental stages examined from day 17 of gestation and adulthood. Thus, both types of Na+ channels are already established at the early stage of neuronal development and appear to be retained throughout the life-span of the DRG neuron. The concentration-response relationships for the block of TTX-sensitive Na+ current by TTX did not appreciably change during development. Although two types of Na+ channels had strikingly different kinetic properties, the kinetic properties of each channel type were basically similar throughout development. The TTX-sensitive Na+ channels were mainly concentrated in cells with large cell diameters throughout developmental stages examined. These large cells appear to correspond to the 'large-light' cells. On the contrary, the TTX-insensitive Na+ channels were found in smaller diameter cells which may correspond to the 'small-dark' cells. Thus, it is concluded that there are heterogeneous categories of neurons which have Na+ channels with different physiological and pharmacological properties. Since Na+ channels play a pivotal role in the action potential generation, these heterogeneity of DRG neurons appear to be instrumental in integrating the sensory signals." @default.
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- W2072269780 title "Ontogenic development of the TTX-sensitive and TTX-insensitive Na+ channels in neurons of the rat dorsal root ganglia" @default.
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- W2072269780 doi "https://doi.org/10.1016/0165-3806(92)90012-l" @default.
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