Matches in SemOpenAlex for { <https://semopenalex.org/work/W2072270959> ?p ?o ?g. }
- W2072270959 endingPage "182" @default.
- W2072270959 startingPage "165" @default.
- W2072270959 abstract "Background: The structure of simian virus 40 (SV40), previously determined at 3.8 å resolution, shows how its pentameric VP1 assembly units are tied together by extended C-terminal arms. In order to define more precisely the possible assembly mechanisms, we have refined the structure at 3.1 å resolution.Results New data from a high-intensity synchrotron source have been used for phase extension by electron-density averaging and refinement, exploiting only the strict 5-fold non-crystallographic symmetry for the real-space averaging steps. The accurate model enables us to study important structural features of the virus particle in detail. The remarkably invariant core of the VP1 pentamer bears the docking sites for the C-terminal arms from other pentamers. These contacts are the principal way in which pentameric assembly units are linked together in the capsid. Only at the interface between five-coordinated and six-coordinated pentamers do the pentamer cores appear to interact strongly. There are two cation-binding sites per VP1 monomer, seen in a soaking experiment with gadolinium nitrate. These sites are quite close to each other at the interfaces between pentamers.Conclusion We propose that the contact between five-coordinated and six-coordinated pentamers may help to generate a six-pentamer nucleus, with which further pentamers can assemble to generate the complete particle. Calcium ions probably stabilize the structure of the assembled particle, rather than direct its assembly." @default.
- W2072270959 created "2016-06-24" @default.
- W2072270959 creator A5000740212 @default.
- W2072270959 creator A5028904289 @default.
- W2072270959 creator A5029265500 @default.
- W2072270959 creator A5040337685 @default.
- W2072270959 date "1996-02-01" @default.
- W2072270959 modified "2023-09-30" @default.
- W2072270959 title "The structure of simian virus 40 refined at 3.1 å resolution" @default.
- W2072270959 cites W1483462340 @default.
- W2072270959 cites W1485283087 @default.
- W2072270959 cites W1500409605 @default.
- W2072270959 cites W1506834377 @default.
- W2072270959 cites W1513674932 @default.
- W2072270959 cites W1528769949 @default.
- W2072270959 cites W1543692383 @default.
- W2072270959 cites W1546896179 @default.
- W2072270959 cites W1551355794 @default.
- W2072270959 cites W1553910668 @default.
- W2072270959 cites W1556205825 @default.
- W2072270959 cites W1556533824 @default.
- W2072270959 cites W1565408377 @default.
- W2072270959 cites W1573534377 @default.
- W2072270959 cites W1577471567 @default.
- W2072270959 cites W1578829886 @default.
- W2072270959 cites W1585895474 @default.
- W2072270959 cites W1587084466 @default.
- W2072270959 cites W1621437655 @default.
- W2072270959 cites W1636640276 @default.
- W2072270959 cites W1674276687 @default.
- W2072270959 cites W1765589188 @default.
- W2072270959 cites W1964485393 @default.
- W2072270959 cites W1972804781 @default.
- W2072270959 cites W1975725195 @default.
- W2072270959 cites W1975914851 @default.
- W2072270959 cites W1975962007 @default.
- W2072270959 cites W1980196242 @default.
- W2072270959 cites W1980581336 @default.
- W2072270959 cites W1985001568 @default.
- W2072270959 cites W1985726900 @default.
- W2072270959 cites W1986191025 @default.
- W2072270959 cites W1989452946 @default.
- W2072270959 cites W1989490595 @default.
- W2072270959 cites W1991022642 @default.
- W2072270959 cites W1996607909 @default.
- W2072270959 cites W2001085828 @default.
- W2072270959 cites W2001641653 @default.
- W2072270959 cites W2002075344 @default.
- W2072270959 cites W2005393972 @default.
- W2072270959 cites W2005760858 @default.
- W2072270959 cites W2008719230 @default.
- W2072270959 cites W2013083986 @default.
- W2072270959 cites W2018522946 @default.
- W2072270959 cites W2023045146 @default.
- W2072270959 cites W2028231353 @default.
- W2072270959 cites W2032078031 @default.
- W2072270959 cites W2033712814 @default.
- W2072270959 cites W2037263249 @default.
- W2072270959 cites W2041123313 @default.
- W2072270959 cites W2042913541 @default.
- W2072270959 cites W2044082153 @default.
- W2072270959 cites W2044731385 @default.
- W2072270959 cites W2049294834 @default.
- W2072270959 cites W2051793369 @default.
- W2072270959 cites W2055290772 @default.
- W2072270959 cites W2060520834 @default.
- W2072270959 cites W2064014934 @default.
- W2072270959 cites W2073268304 @default.
- W2072270959 cites W2079290149 @default.
- W2072270959 cites W2082445870 @default.
- W2072270959 cites W2082890587 @default.
- W2072270959 cites W2106315897 @default.
- W2072270959 cites W2116557030 @default.
- W2072270959 cites W2122109248 @default.
- W2072270959 cites W2140693413 @default.
- W2072270959 cites W2985636467 @default.
- W2072270959 doi "https://doi.org/10.1016/s0969-2126(96)00020-2" @default.
- W2072270959 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8805523" @default.
- W2072270959 hasPublicationYear "1996" @default.
- W2072270959 type Work @default.
- W2072270959 sameAs 2072270959 @default.
- W2072270959 citedByCount "283" @default.
- W2072270959 countsByYear W20722709592012 @default.
- W2072270959 countsByYear W20722709592013 @default.
- W2072270959 countsByYear W20722709592014 @default.
- W2072270959 countsByYear W20722709592015 @default.
- W2072270959 countsByYear W20722709592016 @default.
- W2072270959 countsByYear W20722709592017 @default.
- W2072270959 countsByYear W20722709592018 @default.
- W2072270959 countsByYear W20722709592019 @default.
- W2072270959 countsByYear W20722709592020 @default.
- W2072270959 countsByYear W20722709592021 @default.
- W2072270959 countsByYear W20722709592022 @default.
- W2072270959 countsByYear W20722709592023 @default.
- W2072270959 crossrefType "journal-article" @default.
- W2072270959 hasAuthorship W2072270959A5000740212 @default.
- W2072270959 hasAuthorship W2072270959A5028904289 @default.
- W2072270959 hasAuthorship W2072270959A5029265500 @default.