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• W2072273005 abstract "Deficits in satiation signaling during obesogenic feeding have been proposed to play a role in hyperphagia and weight gain in animals prone to become obese. However, whether this impaired signaling is due to high fat (HF) feeding or to their obese phenotype is still unknown. Therefore, in the current study, we examined the effects of CCK-8 (0.5, 1.0, 2.0, and 4.0 μg/kg) on suppression of food intake of HF-fed obese prone (OP) and resistant (OR) rats. Additionally, we determined the role of endogenous CCK in lipid-induced satiation by measuring plasma CCK levels following a lipid gavage, and tested the effect of pretreatment with devazepide, a CCK-1R antagonist on intragastric lipid-induced satiation. Finally, we examined CCK-1R mRNA levels in the nodose ganglia. We show that OP rats have reduced feeding responses to the low doses of exogenous CCK-8 compared to OR rats. Furthermore, OP rats exhibit deficits in endogenous CCK signaling, as pretreatment with devazepide failed to abolish the reduction in food intake following lipid gavage. These effects were associated with reduced plasma CCK after intragastric lipid in OP but not OR rats. Furthermore, HF feeding resulted in downregulation of CCK-1Rs in the nodose ganglia of OP rats. Collectively, these results demonstrate that HF feeding leads to impairments in lipid-induced CCK satiation signaling in obese-prone rats, potentially contributing to hyperphagia and weight gain." @default.
• W2072273005 created "2016-06-24" @default.
• W2072273005 creator A5018258984 @default.
• W2072273005 creator A5051843940 @default.
• W2072273005 creator A5060613483 @default.
• W2072273005 date "2013-11-01" @default.
• W2072273005 modified "2023-10-15" @default.
• W2072273005 title "Reduced CCK signaling in obese-prone rats fed a high fat diet" @default.
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• W2072273005 doi "https://doi.org/10.1016/j.yhbeh.2013.09.004" @default.
• W2072273005 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24100196" @default.
• W2072273005 hasPublicationYear "2013" @default.
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