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- W2072276076 abstract "In ulcerative colitis the results with a new preparation of budesonide provide a model for development of topically active, orally administered compounds. This approach is promising for the treatment of intestinal inflammation by this class of steroids, which are characterized by high potency and low systemic toxicity. Immunosuppressive treatment in ulcerative colitis remains a form of therapy whose role is uncertain pending large controlled studies that assess both efficacy and safety. For most patients with ulcerative colitis, 5-ASA remains a mainstay of chronic therapy. Although the use of newer mesalamine compounds is widely accepted among gastroenterologists, they appear to have only marginal benefits compared with sulphasalazine and are significantly more expensive. Economic analysis comparing these interventions is necessary. For Crohn's disease, oral steroid therapy remains the cornerstone of treatment and is substantially more effective than dietary therapy. The use of antibiotic therapy to induce remission requires further evaluation in large, randomized controlled trials. Immunosuppressive therapy with the purine antimetabolites or methotrexate is effective and safe for patients who are resistant to, or dependent on, steroid use." @default.
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- W2072276076 date "1997-07-01" @default.
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- W2072276076 title "Medical therapy for inflammatory bowel disease" @default.
- W2072276076 doi "https://doi.org/10.1097/00001574-199707000-00005" @default.
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