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• W2072280802 abstract "Background and Objectives:The purpose of this study was to evaluate whether antioxidant supplementation with tocopherol, vitamin C, β-carotene, and selenium reduces lipid peroxide levels and increases antioxidative enzyme activities in patients with coronary heart disease. Subjects and Methods:Eighty nine patients participated in a randomized, double-blind, placebo-controlled trial. The antioxidant group (45 patients) was given daily doses of tocopherol (400 IU), vitamin C (500 mg), β-carotene (15 mg), and selenium (50 μg) and the placebo group (44) received placebo. Thirty eight of the antioxidant group (84.4%) and thirty nine (88.6%) of the placebo group completed the 3-month supplementation. Results:Serum levels of α-tocopherol, vitamin C and β-carotene were significantly increased in the antioxidant group as compared to the placebo group (p<0.05), however, retinol was not. Thiobarbituric acid-reactive substances (TBARS) decreased significantly (0.6 nmol MDA/mL) in the antioxidant group as compared with the level (0.09 nmol MDA/mL) seen in the placebo group (p<0.05). Antioxidants did not affect the oxidized-LDL level. The activities of erythrocyte superoxide dismutase (SOD) significantly increased by 0.85 unit/mg hemoglobin in the antioxidant group versus 0.27 unit/mg hemoglobin in the placebo group (p<0.01), and the activities of erythrocyte catalase significantly decreased by 0.04 unit/mg hemoglobin versus 3.37 unit/mg hemoglobin (p<0.01). However, the activities of erythrocyte glutathione peroxidase (GPX) increased insignificantly by 0.09 unit/mg hemoglobin vs 0.1 unit/mg hemoglobin. Conclusion:These results suggest that antioxidant supplementation with tocopherol, vitamin C, 논문접수일:2001년 10월 31일 심사완료일:2001년 11월 3일 교신저자:전재은, 700-422 대구광역시 중구 삼덕2가 50 경북대학교 의과대학 내과학교실 전화:(053) 420-5526·전송:(053) 426-2046·E-mail:jejun@knu.ac.kr" @default.
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• W2072280802 date "2001-01-01" @default.
• W2072280802 modified "2023-09-24" @default.
• W2072280802 title "Effects of Antioxidant Supplementation on the Lipid Peroxidation and Antioxidative Enzyme Activities in Patients with Coronary Heart Disease" @default.
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• W2072280802 doi "https://doi.org/10.4070/kcj.2001.31.11.1215" @default.
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