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• W2072295462 abstract "Background: Antihistamines are the most commonly prescribed class of medication for perennial allergic rhinitis (PAR). The primary objective of this study was to determine whether levocetirizine (Xyzal ® ), the active enantiomer of cetirizine, could achieve at least a 50% improvement in PAR symptoms compared to the placebo over the first week of treatment. Methods: A total of 294 patients with PAR due to house dust mites were randomized in this 8‐week double‐blind, placebo‐controlled, multicentre trial to receive either levocetirizine 5 mg/day or placebo. Mean Total Four‐Symptom Scores (T4SS) (nasal pruritus, ocular pruritus, rhinorrhoea and sneezing) were compared between treatment groups over weeks 1, 4 and 6. All individual symptom scores, including nasal congestion, were also studied. Results: Levocetirizine showed an 86% improvement in T4SS over the first week of treatment and a 47% improvement over the entire treatment period compared with placebo. Absolute changes from baseline were 3.64 and 2.47 for levocetirizine and placebo, respectively. Individual symptom scores showed statistically significant ( P ≤ 0.01) differences in favour of levocetirizine for all study time‐points. Nasal congestion was unexpectedly significantly improved ( P < 0.001). The incidence of reported adverse events was comparable between treatment and placebo group. Conclusions: Levocetirizine 5 mg/day is an effective and well‐tolerated treatment of PAR. In addition, levocetirizine is effective for the relief of nasal congestio." @default.
• W2072295462 created "2016-06-24" @default.
• W2072295462 creator A5063501912 @default.
• W2072295462 date "2003-08-04" @default.
• W2072295462 modified "2023-10-16" @default.
• W2072295462 title "Levocetirizine is effective for symptom relief including nasal congestion in adolescent and adult (PAR) sensitized to house dust mites" @default.
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• W2072295462 doi "https://doi.org/10.1034/j.1398-9995.2003.00171.x" @default.
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