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- W2072297390 abstract "A series of phenanthro and acenaphtho azaquinolizinium salts was selected as model heterocyclic polyaromatic compounds to study their interaction with deoxyribonucleic acid (DNA). The compounds exhibit a notable native fluorescence ( u em = 450-520 nm) in buffered aqueous solutions, as expected from planar aromatic heterocycles. However, in the presence of increasing concentrations of DNA (0, 10-90 mg/L), a loss of up to 90% of the fluorescence is observed. This fluorescence quenching can be explained by the interaction of the polycyclic ring and DNA. Application of the Stern-Volmer treatment (correlation coefficient 0.9) reveals the existence of a quenching process. The study of the interaction by UV-Vis spectrophotometry showed slight shifts (5-10 nm) in the absorption maxima of all compounds together with a decrease in the absorbance. Viscosimetry experiments confirm the association of these molecules with DNA as indicated by the increase (12-36%) of the reduced viscosity of the solutions in the presence of DNA. Equilibrium dialysis studies confirm that all compounds are bound to DNA (5-50%). These results lead to the conclusion that DNA interaction is due mainly to the carbocyclic system rather than to the heterocyclic moiety, suggesting that it takes place through hydrophobic interactions." @default.
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- W2072297390 date "2002-01-01" @default.
- W2072297390 modified "2023-09-30" @default.
- W2072297390 title "A Study of the Interaction of Polycyclic Derivatives of Azaquinolizinium Salts with DNA" @default.
- W2072297390 doi "https://doi.org/10.1080/10406630210373" @default.
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