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• W2072306117 abstract "A 2‐ to 3‐fold increase of GTP cyclohydrolase I (E.C. 3.5.4.16), the key enzyme of tetrahydrobiopterin biosynthesis from GTP, was observed in cerebellum, remaining brain, liver, spleen, and adrenal gland of rats treated with a single dose of lipopolysaccharide (LPS). This led to increased biopterin levels in tissues but not in plasma. Parallel induction of nitric oxide (NO) synthase was indicated by a 10‐ to 100‐fold increase of plasma nitrate levels 6 and 12 hours after injection of LPS. Furthermore, systolic blood pressure was reduced significantly by 23%. Our results demonstrate induction of tetrahydrobiopterin biosynthesis after LPS treatment in vivo." @default.
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• W2072306117 date "1993-05-17" @default.
• W2072306117 modified "2023-10-14" @default.
• W2072306117 title "Induction of GTP cyclohydrolase I by bacterial lipopolysaccharide in the rat" @default.
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• W2072306117 doi "https://doi.org/10.1016/0014-5793(93)81574-j" @default.
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