FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2072322839> ?p ?o ?g. }

• W2072322839 endingPage "e14825" @default.
• W2072322839 startingPage "e14825" @default.
• W2072322839 abstract "Classical quantitative trait loci (QTL) analysis and gene expression QTL (eQTL) were combined to identify the causal gene (or QTG) underlying a highly significant QTL controlling the variation of breast meat color in a F2 cross between divergent high-growth (HG) and low-growth (LG) chicken lines. Within this meat quality QTL, BCMO1 (Accession number GenBank: AJ271386), encoding the β-carotene 15, 15'-monooxygenase, a key enzyme in the conversion of β-carotene into colorless retinal, was a good functional candidate. Analysis of the abundance of BCMO1 mRNA in breast muscle of the HG x LG F2 population allowed for the identification of a strong cis eQTL. Moreover, reevaluation of the color QTL taking BCMO1 mRNA levels as a covariate indicated that BCMO1 mRNA levels entirely explained the variations in meat color. Two fully-linked single nucleotide polymorphisms (SNP) located within the proximal promoter of BCMO1 gene were identified. Haplotype substitution resulted in a marked difference in BCMO1 promoter activity in vitro. The association study in the F2 population revealed a three-fold difference in BCMO1 expression leading to a difference of 1 standard deviation in yellow color between the homozygous birds at this haplotype. This difference in meat yellow color was fully consistent with the difference in carotenoid content (i.e. lutein and zeaxanthin) evidenced between the two alternative haplotypes. A significant association between the haplotype, the level of BCMO1 expression and the yellow color of the meat was also recovered in an unrelated commercial broiler population. The mutation could be of economic importance for poultry production by making possible a gene-assisted selection for color, a determining aspect of meat quality. Moreover, this natural genetic diversity constitutes a new model for the study of β-carotene metabolism which may act upon diverse biological processes as precursor of the vitamin A." @default.
• W2072322839 created "2016-06-24" @default.
• W2072322839 creator A5001959821 @default.
• W2072322839 creator A5005467044 @default.
• W2072322839 creator A5011077096 @default.
• W2072322839 creator A5034317890 @default.
• W2072322839 creator A5042573135 @default.
• W2072322839 creator A5065417179 @default.
• W2072322839 creator A5067090682 @default.
• W2072322839 creator A5073228322 @default.
• W2072322839 creator A5077540285 @default.
• W2072322839 creator A5078079540 @default.
• W2072322839 creator A5078512785 @default.
• W2072322839 creator A5084849751 @default.
• W2072322839 creator A5089712558 @default.
• W2072322839 date "2011-07-05" @default.
• W2072322839 modified "2023-10-18" @default.
• W2072322839 title "Detection of a Cis eQTL Controlling BMCO1 Gene Expression Leads to the Identification of a QTG for Chicken Breast Meat Color" @default.
• W2072322839 cites W1549672567 @default.
• W2072322839 cites W1551401951 @default.
• W2072322839 cites W1975680342 @default.
• W2072322839 cites W1982125304 @default.
• W2072322839 cites W2017767012 @default.
• W2072322839 cites W2023699618 @default.
• W2072322839 cites W2029522112 @default.
• W2072322839 cites W2034190870 @default.
• W2072322839 cites W2034801970 @default.
• W2072322839 cites W2044711113 @default.
• W2072322839 cites W2054349164 @default.
• W2072322839 cites W2064986218 @default.
• W2072322839 cites W2071179936 @default.
• W2072322839 cites W2078921877 @default.
• W2072322839 cites W2088320364 @default.
• W2072322839 cites W2097064013 @default.
• W2072322839 cites W2108244474 @default.
• W2072322839 cites W2108908271 @default.
• W2072322839 cites W2109168861 @default.
• W2072322839 cites W2125860227 @default.
• W2072322839 cites W2126738866 @default.
• W2072322839 cites W2134604122 @default.
• W2072322839 cites W2146566129 @default.
• W2072322839 cites W2147512054 @default.
• W2072322839 cites W2166145244 @default.
• W2072322839 cites W2197761336 @default.
• W2072322839 doi "https://doi.org/10.1371/journal.pone.0014825" @default.
• W2072322839 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3130028" @default.
• W2072322839 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21750696" @default.
• W2072322839 hasPublicationYear "2011" @default.
• W2072322839 type Work @default.
• W2072322839 sameAs 2072322839 @default.
• W2072322839 citedByCount "37" @default.
• W2072322839 countsByYear W20723228392012 @default.
• W2072322839 countsByYear W20723228392013 @default.
• W2072322839 countsByYear W20723228392014 @default.
• W2072322839 countsByYear W20723228392015 @default.
• W2072322839 countsByYear W20723228392016 @default.
• W2072322839 countsByYear W20723228392017 @default.
• W2072322839 countsByYear W20723228392018 @default.
• W2072322839 countsByYear W20723228392019 @default.
• W2072322839 countsByYear W20723228392020 @default.
• W2072322839 countsByYear W20723228392021 @default.
• W2072322839 countsByYear W20723228392022 @default.
• W2072322839 countsByYear W20723228392023 @default.
• W2072322839 crossrefType "journal-article" @default.
• W2072322839 hasAuthorship W2072322839A5001959821 @default.
• W2072322839 hasAuthorship W2072322839A5005467044 @default.
• W2072322839 hasAuthorship W2072322839A5011077096 @default.
• W2072322839 hasAuthorship W2072322839A5034317890 @default.
• W2072322839 hasAuthorship W2072322839A5042573135 @default.
• W2072322839 hasAuthorship W2072322839A5065417179 @default.
• W2072322839 hasAuthorship W2072322839A5067090682 @default.
• W2072322839 hasAuthorship W2072322839A5073228322 @default.
• W2072322839 hasAuthorship W2072322839A5077540285 @default.
• W2072322839 hasAuthorship W2072322839A5078079540 @default.
• W2072322839 hasAuthorship W2072322839A5078512785 @default.
• W2072322839 hasAuthorship W2072322839A5084849751 @default.
• W2072322839 hasAuthorship W2072322839A5089712558 @default.
• W2072322839 hasBestOaLocation W20723228391 @default.
• W2072322839 hasConcept C104317684 @default.
• W2072322839 hasConcept C135763542 @default.
• W2072322839 hasConcept C153209595 @default.
• W2072322839 hasConcept C168393362 @default.
• W2072322839 hasConcept C180754005 @default.
• W2072322839 hasConcept C197754878 @default.
• W2072322839 hasConcept C2908647359 @default.
• W2072322839 hasConcept C54355233 @default.
• W2072322839 hasConcept C69991583 @default.
• W2072322839 hasConcept C71924100 @default.
• W2072322839 hasConcept C81941488 @default.
• W2072322839 hasConcept C86803240 @default.
• W2072322839 hasConcept C99454951 @default.
• W2072322839 hasConceptScore W2072322839C104317684 @default.
• W2072322839 hasConceptScore W2072322839C135763542 @default.
• W2072322839 hasConceptScore W2072322839C153209595 @default.
• W2072322839 hasConceptScore W2072322839C168393362 @default.
• W2072322839 hasConceptScore W2072322839C180754005 @default.
• W2072322839 hasConceptScore W2072322839C197754878 @default.
• W2072322839 hasConceptScore W2072322839C2908647359 @default.

• next