FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2072322981> ?p ?o ?g. }

• W2072322981 endingPage "193" @default.
• W2072322981 startingPage "188" @default.
• W2072322981 abstract "Progesterone stimulation of the estradiol (E2)-primed human endometrium initiates DZ of the stromal cells around the spiral arterioles. Under continued steroid stimulation, DZ spreads wave-like to establish the decidual cell as a major cell type of the luteal phase and pregnant endometrium. Because of their widespread distribution throughout the endometrium and concentration at perivascular sites, decidual cells are spatially and temporally positioned to mediate the opposing requirements of maintaining hemostasis during endovascular trophoblast invasion, yet promoting menstrual hemorrhage in the absence of implantation. The experimental results summarized in this review indicate that the paradoxical properties manifested by endometrial stromal/decidual cells are controlled by several proteins with either hemostatic or ECM-degrading or vasoactive activity, and that their expression is altered in response to changes in levels of circulating ovarian steroids during the menstrual cycle. These conclusions are drawn primarily from studies with a well-characterized in vitro model of DZ using monolayers of stromal cells derived from specimens of predecidualized endometrium. Thus, progestins modify the expression of several DZ-related markers in the cultured stromal cells, and E2 enhances these effects despite the lack of response to E2 alone. These responses are consistent with the differential actions displayed by E2 and progesterone in vivo, by which E2 primes the endometrium for the decidualizing effects of progesterone by elevating progesterone receptor levels. Accordingly, during steroid-induced in vitro DZ, a marked increase in the expression of stromal cell TF and PAI-1 and reciprocal inhibition of tPA activity suggest mechanisms to account for the absence of hemorrhage during invasion of the endometrial vasculature by implanting trophoblasts. In contrast to steroid-induced DZ, the events of menstruation are initiated in response to a decline in circulating levels of ovarian steroids. Accordingly, subjecting in vitro decidualized stromal cells to steroid withdrawal results in pronounced reversal in the expression of all of the end points listed above. Consequently, the local hemostatic environment is transformed into a hemorrhage-promoting milieu. Taken together with vascular injury resulting from ischemia induced by spiral artery vasoconstriction, the net effect is attainment of two prerequisites for menstrual hemorrhage, vascular injury and inadequate hemostasis." @default.
• W2072322981 created "2016-06-24" @default.
• W2072322981 creator A5005680652 @default.
• W2072322981 creator A5011581818 @default.
• W2072322981 creator A5034967157 @default.
• W2072322981 creator A5042446627 @default.
• W2072322981 creator A5086200879 @default.
• W2072322981 date "1997-09-01" @default.
• W2072322981 modified "2023-10-01" @default.
• W2072322981 title "Decidual Cell Regulation of Hemostasis during Implantation and Menstruation" @default.
• W2072322981 cites W1451684643 @default.
• W2072322981 cites W1482195692 @default.
• W2072322981 cites W1506021195 @default.
• W2072322981 cites W1894541755 @default.
• W2072322981 cites W1949259756 @default.
• W2072322981 cites W1980952325 @default.
• W2072322981 cites W1989021590 @default.
• W2072322981 cites W1994339372 @default.
• W2072322981 cites W1995721306 @default.
• W2072322981 cites W1997290401 @default.
• W2072322981 cites W2000010699 @default.
• W2072322981 cites W2006115216 @default.
• W2072322981 cites W2048984796 @default.
• W2072322981 cites W2084046924 @default.
• W2072322981 cites W2093936306 @default.
• W2072322981 cites W2110828317 @default.
• W2072322981 cites W2145733556 @default.
• W2072322981 cites W2241768283 @default.
• W2072322981 cites W2295027276 @default.
• W2072322981 cites W2336040302 @default.
• W2072322981 cites W4235412160 @default.
• W2072322981 cites W4235732274 @default.
• W2072322981 cites W4236187855 @default.
• W2072322981 cites W4237436732 @default.
• W2072322981 cites W4243891409 @default.
• W2072322981 cites W4248140912 @default.
• W2072322981 cites W4251527986 @default.
• W2072322981 cites W4251715904 @default.
• W2072322981 doi "https://doi.org/10.1111/j.1749-6632.1997.tb48539.x" @default.
• W2072322981 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9329839" @default.
• W2072322981 hasPublicationYear "1997" @default.
• W2072322981 type Work @default.
• W2072322981 sameAs 2072322981 @default.
• W2072322981 citedByCount "24" @default.
• W2072322981 countsByYear W20723229812013 @default.
• W2072322981 countsByYear W20723229812014 @default.
• W2072322981 countsByYear W20723229812017 @default.
• W2072322981 countsByYear W20723229812018 @default.
• W2072322981 countsByYear W20723229812019 @default.
• W2072322981 countsByYear W20723229812020 @default.
• W2072322981 countsByYear W20723229812022 @default.
• W2072322981 crossrefType "journal-article" @default.
• W2072322981 hasAuthorship W2072322981A5005680652 @default.
• W2072322981 hasAuthorship W2072322981A5011581818 @default.
• W2072322981 hasAuthorship W2072322981A5034967157 @default.
• W2072322981 hasAuthorship W2072322981A5042446627 @default.
• W2072322981 hasAuthorship W2072322981A5086200879 @default.
• W2072322981 hasConcept C126322002 @default.
• W2072322981 hasConcept C134018914 @default.
• W2072322981 hasConcept C143228043 @default.
• W2072322981 hasConcept C16930146 @default.
• W2072322981 hasConcept C172680121 @default.
• W2072322981 hasConcept C185592680 @default.
• W2072322981 hasConcept C2776953305 @default.
• W2072322981 hasConcept C2778316770 @default.
• W2072322981 hasConcept C2778589496 @default.
• W2072322981 hasConcept C2779234561 @default.
• W2072322981 hasConcept C2779742232 @default.
• W2072322981 hasConcept C2781107390 @default.
• W2072322981 hasConcept C54355233 @default.
• W2072322981 hasConcept C71315377 @default.
• W2072322981 hasConcept C71924100 @default.
• W2072322981 hasConcept C86803240 @default.
• W2072322981 hasConceptScore W2072322981C126322002 @default.
• W2072322981 hasConceptScore W2072322981C134018914 @default.
• W2072322981 hasConceptScore W2072322981C143228043 @default.
• W2072322981 hasConceptScore W2072322981C16930146 @default.
• W2072322981 hasConceptScore W2072322981C172680121 @default.
• W2072322981 hasConceptScore W2072322981C185592680 @default.
• W2072322981 hasConceptScore W2072322981C2776953305 @default.
• W2072322981 hasConceptScore W2072322981C2778316770 @default.
• W2072322981 hasConceptScore W2072322981C2778589496 @default.
• W2072322981 hasConceptScore W2072322981C2779234561 @default.
• W2072322981 hasConceptScore W2072322981C2779742232 @default.
• W2072322981 hasConceptScore W2072322981C2781107390 @default.
• W2072322981 hasConceptScore W2072322981C54355233 @default.
• W2072322981 hasConceptScore W2072322981C71315377 @default.
• W2072322981 hasConceptScore W2072322981C71924100 @default.
• W2072322981 hasConceptScore W2072322981C86803240 @default.
• W2072322981 hasIssue "1 Uterus, The" @default.
• W2072322981 hasLocation W20723229811 @default.
• W2072322981 hasLocation W20723229812 @default.
• W2072322981 hasOpenAccess W2072322981 @default.
• W2072322981 hasPrimaryLocation W20723229811 @default.
• W2072322981 hasRelatedWork W2072322981 @default.
• W2072322981 hasRelatedWork W2358522016 @default.
• W2072322981 hasRelatedWork W2461142089 @default.
• W2072322981 hasRelatedWork W2766711782 @default.

• next