FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2072326250> ?p ?o ?g. }

• W2072326250 endingPage "332" @default.
• W2072326250 startingPage "321" @default.
• W2072326250 abstract "The basal nucleus of Meynert (BNM) provides the primary cholinergic inputs to the cerebral cortex. Loss of neurons in the BNM is linked to cognitive deficits in Alzheimer's disease and other degenerative conditions. Numerous animal studies described cholinergic and non-cholinergic neuronal responses in the BNM; however, work in humans has been hampered by the difficulty of defining the BNM anatomically. Here, on the basis of a previous study that delineated the BNM of post-mortem human brains in a standard stereotaxic space, we sought to examine functional connectivity of the BNM, as compared to the nucleus accumbens (or ventral striatum, VS), in a large resting state functional magnetic resonance imaging data set. The BNM and VS shared but also showed a distinct pattern of cortical and subcortical connectivity. Compared to the VS, the BNM showed stronger positive connectivity with the putamen, pallidum, thalamus, amygdala and midbrain, as well as the anterior cingulate cortex, supplementary motor area and pre-supplementary motor area, a network of brain regions that respond to salient stimuli and orchestrate motor behavior. In contrast, compared to the BNM, the VS showed stronger positive connectivity with the ventral caudate and medial orbitofrontal cortex, areas implicated in reward processing and motivated behavior. Furthermore, the BNM and VS each showed extensive negative connectivity with visual and lateral prefrontal cortices. Together, the distinct cerebral functional connectivities support the role of the BNM in arousal, saliency responses and cognitive motor control and the VS in reward related behavior. Considering the importance of BNM in age-related cognitive decline, we explored the effects of age on BNM and VS connectivities. BNM connectivity to the visual and somatomotor cortices decreases while connectivity to subcortical structures including the midbrain, thalamus, and pallidum increases with age. These findings of age-related changes of cerebral functional connectivity of the BNM may facilitate research of the neural bases of cognitive decline in health and illness." @default.
• W2072326250 created "2016-06-24" @default.
• W2072326250 creator A5021695968 @default.
• W2072326250 creator A5040052604 @default.
• W2072326250 creator A5047855118 @default.
• W2072326250 creator A5054640156 @default.
• W2072326250 creator A5075317805 @default.
• W2072326250 creator A5087805638 @default.
• W2072326250 date "2014-08-01" @default.
• W2072326250 modified "2023-10-15" @default.
• W2072326250 title "Resting state functional connectivity of the basal nucleus of Meynert in humans: In comparison to the ventral striatum and the effects of age" @default.
• W2072326250 cites W1232035395 @default.
• W2072326250 cites W1587160774 @default.
• W2072326250 cites W1600050350 @default.
• W2072326250 cites W1660666227 @default.
• W2072326250 cites W1760829075 @default.
• W2072326250 cites W192525415 @default.
• W2072326250 cites W1965325756 @default.
• W2072326250 cites W1966805834 @default.
• W2072326250 cites W1967629764 @default.
• W2072326250 cites W1969397636 @default.
• W2072326250 cites W1970695058 @default.
• W2072326250 cites W1972522479 @default.
• W2072326250 cites W1976206766 @default.
• W2072326250 cites W1977615319 @default.
• W2072326250 cites W1979532115 @default.
• W2072326250 cites W1980436365 @default.
• W2072326250 cites W1981449019 @default.
• W2072326250 cites W1982327643 @default.
• W2072326250 cites W1987777969 @default.
• W2072326250 cites W1990134753 @default.
• W2072326250 cites W1990472336 @default.
• W2072326250 cites W1992693193 @default.
• W2072326250 cites W1994517886 @default.
• W2072326250 cites W1996176318 @default.
• W2072326250 cites W1996900261 @default.
• W2072326250 cites W2004601147 @default.
• W2072326250 cites W2006312249 @default.
• W2072326250 cites W2006521913 @default.
• W2072326250 cites W2008607322 @default.
• W2072326250 cites W2009494091 @default.
• W2072326250 cites W2011481459 @default.
• W2072326250 cites W2011700455 @default.
• W2072326250 cites W2013854477 @default.
• W2072326250 cites W2015354104 @default.
• W2072326250 cites W2016186194 @default.
• W2072326250 cites W2016519439 @default.
• W2072326250 cites W2017469293 @default.
• W2072326250 cites W2019161608 @default.
• W2072326250 cites W2026706150 @default.
• W2072326250 cites W2029390827 @default.
• W2072326250 cites W2034410483 @default.
• W2072326250 cites W2034630192 @default.
• W2072326250 cites W2035051064 @default.
• W2072326250 cites W2035289099 @default.
• W2072326250 cites W2038292797 @default.
• W2072326250 cites W2039261561 @default.
• W2072326250 cites W2042249181 @default.
• W2072326250 cites W2044333499 @default.
• W2072326250 cites W2045118554 @default.
• W2072326250 cites W2045804286 @default.
• W2072326250 cites W2046250855 @default.
• W2072326250 cites W2047250466 @default.
• W2072326250 cites W2047746975 @default.
• W2072326250 cites W2047751255 @default.
• W2072326250 cites W2048802499 @default.
• W2072326250 cites W2052094038 @default.
• W2072326250 cites W2052534327 @default.
• W2072326250 cites W2056674659 @default.
• W2072326250 cites W2057415339 @default.
• W2072326250 cites W2058578514 @default.
• W2072326250 cites W2059708992 @default.
• W2072326250 cites W2060523026 @default.
• W2072326250 cites W2060594713 @default.
• W2072326250 cites W2062636034 @default.
• W2072326250 cites W2064073119 @default.
• W2072326250 cites W2064797937 @default.
• W2072326250 cites W2067827640 @default.
• W2072326250 cites W2070530186 @default.
• W2072326250 cites W2073093666 @default.
• W2072326250 cites W2075582885 @default.
• W2072326250 cites W2076358196 @default.
• W2072326250 cites W2076366709 @default.
• W2072326250 cites W2076434927 @default.
• W2072326250 cites W2076683771 @default.
• W2072326250 cites W2077083081 @default.
• W2072326250 cites W2080847728 @default.
• W2072326250 cites W2081718320 @default.
• W2072326250 cites W2082714165 @default.
• W2072326250 cites W2082842353 @default.
• W2072326250 cites W2085068274 @default.
• W2072326250 cites W2085952282 @default.
• W2072326250 cites W2090330517 @default.
• W2072326250 cites W2091005110 @default.
• W2072326250 cites W2091479457 @default.
• W2072326250 cites W2091928228 @default.
• W2072326250 cites W2093146198 @default.
• W2072326250 cites W2093972428 @default.

• next