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• W2072331657 endingPage "871" @default.
• W2072331657 startingPage "863" @default.
• W2072331657 abstract "The expression of some insect P450 genes can be induced by both exogenous and endogenous compounds and there is evidence to suggest that multiple constitutively overexpressed P450 genes are co-responsible for the development of resistance to permethrin in resistant mosquitoes. This study characterized the permethrin induction profiles of P450 genes known to be constitutively overexpressed in resistant mosquitoes, Culex quinquefasciatus. The gene expression in 7 of the 19 P450 genes CYP325K3v1, CYP4D42v2, CYP9J45, (CYP) CPIJ000926, CYP325G4, CYP4C38, CYP4H40 in the HAmCqG8 strain, increased more than 2-fold after exposure to permethrin at an LC50 concentration (10 ppm) compared to their acetone treated counterpart; no significant differences in the expression of these P450 genes in susceptible S-Lab mosquitoes were observed after permethrin treatment. Eleven of the fourteen P450 genes overexpressed in the MAmCqG6 strain, CYP9M10, CYP6Z12, CYP9J33, CYP9J43, CYP9J34, CYP306A1, CYP6Z15, CYP9J45, CYPPAL1, CYP4C52v1, CYP9J39, were also induced more than doubled after exposure to an LC50 (0.7 ppm) dose of permethrin. No significant induction in P450 gene expression was observed in the susceptible S-Lab mosquitoes after permethrin treatment except for CYP6Z15 and CYP9J39, suggesting that permethrin induction of these two P450 genes are common to both susceptible and resistant mosquitoes while the induction of the others are specific to insecticide resistant mosquitoes. These results demonstrate that multiple P450 genes are co-up-regulated in insecticide resistant mosquitoes through both constitutive overexpression and induction mechanisms, providing additional support for their involvement in the detoxification of insecticides and the development of insecticide resistance." @default.
• W2072331657 created "2016-06-24" @default.
• W2072331657 creator A5008199746 @default.
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• W2072331657 creator A5061817335 @default.
• W2072331657 creator A5072698553 @default.
• W2072331657 creator A5073960619 @default.
• W2072331657 date "2013-01-01" @default.
• W2072331657 modified "2023-10-16" @default.
• W2072331657 title "Permethrin Induction of Multiple Cytochrome P450 Genes in Insecticide Resistant Mosquitoes, <i>Culex quinquefasciatus</i>" @default.
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• W2072331657 doi "https://doi.org/10.7150/ijbs.6744" @default.
• W2072331657 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3805894" @default.
• W2072331657 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24155662" @default.
• W2072331657 hasPublicationYear "2013" @default.
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