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- W2072336293 abstract "The abnormal activated Protein C (APC) cofactor recognised by Dahlback and colleagues (1), as a cause of APC resistance, is now known to be due to a mutation in the Factor V molecule resulting in a defect in the APC cofactor, termed Factor V Leiden (2). By adding exogenous APC to an Activated Partial Thromboplastin Time (APTT) reagent, Dahlback introduced the ratio of APC APTT/ ordinary APTT as a diagnostic test. A ratio of > 2.0 indicated normal APC cofactor and a ratio of < 2.0 indicated an APC cofactor defect. Addition of preformed APC to plasma, bypasses endogenous Protein C (PC) and Protein S (PS). In order to characterise the three different defects, PC, PS and APC cofactor, it is necessary to perform three separate specific assays as part of a thrombophilia screen." @default.
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- W2072336293 date "1996-01-01" @default.
- W2072336293 modified "2023-09-26" @default.
- W2072336293 title "A more discriminating test for APC resistance and a possible screening test to include protein C and protein S" @default.
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- W2072336293 doi "https://doi.org/10.1016/0049-3848(95)00223-5" @default.
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