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• W2072336411 abstract "Nasopharyngeal carcinoma (NPC) is an Epstein-Barr virus (EBV) associated malignant tumor. Recently, cidofovir, an anti-viral drug which is an acyclic nucleoside analogue, has been reported to have an anti-tumor potential. Two patients with NPC, who had previously received multi-round therapy, were treated with cidofovir. Cidofovir was topically injected in and around the tumor once every 3 weeks (originally 75 mg/ml sulution, diluted to 15 mg/ml just before injection, 37.5 mg of cidofovir at a time). Tumor growth was suppressed for several months around the injection site in each patient. EBV-encoded RNAs in situ hybridization revealed the reduction of the tumor cell population; however, the EBER expression was still maintained in the NPC tumor cells. Although the anti-tumor mechanism remains unclear, these results suggest that cidofovir is actually an effective and safe agent for the treatment of NPC." @default.
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• W2072336411 date "2008-01-01" @default.
• W2072336411 modified "2023-09-26" @default.
• W2072336411 title "Treatment of locally recurrent epstein–barr virus-associated nasopharyngeal carcinoma using the anti-viral agent cidofovir" @default.
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• W2072336411 doi "https://doi.org/10.1002/jmv.21165" @default.
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